Dorsal hippocampal brain receptor complexes linked to the protein synthesis-dependent late phase (LTP) in the rat

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• 作者：Lin Li (1)
  Han Wang (2)
  Maryam Ghafari (1)
  Gunyong An (1)
  Volker Korz (2)
  Gert Lubec (1)
  
  1. Department of Pediatrics ; Medical University of Vienna ; W盲hringer G眉rtel 18-20 ; 1090 ; Vienna ; Austria
  2. Institute of Biology ; Otto von Guericke University Magdeburg ; 39120 ; Magdeburg ; Germany
  
• 关键词：LTP ; Hippocampus ; Brain receptor complexes
• 刊名：Brain Structure and Function
• 出版年：2015
• 出版时间：March 2015
• 年：2015
• 卷：220
• 期：2
• 页码：1051-1062
• 全文大小：1,665 KB
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• 刊物主题：Neurosciences; Cell Biology; Neurology;
• 出版者：Springer Berlin Heidelberg
• ISSN：1863-2661

文摘

In order to link major brain receptor complex levels to in vivo electrically induced LTP, a bipolar stimulation electrode was chronically implanted into the perforant path, while two monopolar recording electrodes were implanted into the dentate gyrus of the dorsal hippocampus. The recording electrode was measuring extracellular excitatory postsynaptic potentials, while the other one measured population spikes. Immunoblotting of native receptor proteins was carried out in the DH based upon blue-native gel electrophoresis and immunoprecipitation followed by mass spectrometrical identification of the NR1-GluA1-GluA2 complex was used to provide evidence for complex formation. The induction of LTP in DH was proven and NMDA receptor complex levels containing NR1, GluA1, GluA2 and GluA3 were modulated by LTP induction. The LTP-associated changes of receptor complex levels may indicate concerted action, interaction and represent a pattern of major brain receptor complexes in the DH following electrical induction of LTP in the rat.