Genetic polymorphisms of pharmacogenomic VIP variants in the Uygur population from northwestern China
详细信息 查看全文
- 作者：Li Wang ; Ainiwaer Aikemu ; Ayiguli Yibulayin ; Shuli Du ; Tingting Geng…
- 关键词：Pharmacogenomics ; genetic polymorphisms ; Uygur ; VIP variants
- 刊名：BMC Genetics
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：16
- 期：1
- 全文大小：874 KB
- 刊物主题：Life Sciences, general; Animal Genetics and Genomics; Microbial Genetics and Genomics; Plant Genetics & Genomics; Genetics and Population Dynamics;
- 出版者：BioMed Central
- ISSN：1471-2156
文摘
Background Drug response variability observed amongst patients is caused by the interaction of both genetic and non-genetic factors, and frequencies of functional genetic variants are known to vary amongst populations. Pharmacogenomic research has the potential to help with individualized treatments. We have not found any pharmacogenomics information regarding Uygur ethnic group in northwest China. In the present study, we genotyped 85 very important pharmacogenetic (VIP) variants (selected from the PharmGKB database) in the Uygur population and compared our data with other eleven populations from the HapMap data set.