Effects of analogue insulin in multiple daily injection therapy of type 2 diabetes on postprandial glucose control and cardiac function compared to human insulin: a randomized controlled long-term study

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• 作者：Helene von Bibra ; Thorsten Siegmund ; Iris Kingreen…
• 关键词：Analogue insulins ; Human insulin ; Postprandial glucose ; Metabolic control ; Diastolic cardiac function ; Insulin resistance ; Type 2 diabetes ; Diastolic dysfunction
• 刊名：Cardiovascular Diabetology
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：15
• 期：1
• 全文大小：1,039 KB
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• 作者单位：Helene von Bibra (1)
  Thorsten Siegmund (1)
  Iris Kingreen (1)
  Markus Riemer (1)
  Tibor Schuster (2)
  Petra-Maria Schumm-Draeger (1)
  
  1. Clinic for Endocrinology, Diabetes and Vascular Medicine, Klinikum Bogenhausen, Städt. Klinikum München GmbH, Munich, Germany
  2. Institute for Statistics and Epidemiology in Medicine of the Technische Universität, Munich, Germany
  
• 刊物主题：Diabetes; Angiology; Cardiology;
• 出版者：BioMed Central
• ISSN：1475-2840

文摘

Background The prevention of cardiovascular disease, including diastolic cardiac dysfunction with its high prevalence and ominous prognosis, is a therapeutic challenge for patients with type 2 diabetes. Both short and long-acting insulin analogues (AI) have been shown to reduce glucose variability and provide potential benefit for cardiovascular disease although the effects on cardiac function have not yet been evaluated. This long-term, prospective, randomized controlled trial in patients with type 2 diabetes (T2D) tested the hypothesis that a multiple daily injection regimen (MDI) with AI improves postmeal glucose excursions in comparison to human insulin (HI) and that the effects of AI improve diastolic cardiac function.