Effects of a healthy Nordic diet on plasma 25-hydroxyvitamin D concentration in subjects with metabolic syndrome: a randomized, placebo-controlled trial (SYSDIET)
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- 作者：Lea Brader (1)
Lars Rejnmark (1)
Carsten Carlberg (2)
Ursula Schwab (3)
Marjukka Kolehmainen (3)
Fredrik Rosqvist (4)
Lieselotte Cloetens (5)
Mona Landin-Olsson (6)
Ingibjorg Gunnarsdottir (7)
Kaisa S. Poutanen (3)
Karl-Heinz Herzig (8) (9)
Ulf Risérus (4)
Markku J. Savolainen (10) (11)
Inga Thorsdottir (7)
Matti Uusitupa (3)
Kjeld Hermansen (1) - 关键词：Vitamin D ; 25 ; hydroxyvitamin D ; Healthy Nordic diet ; Nordic nutrition recommendations ; Metabolic syndrome
- 刊名：European Journal of Nutrition
- 出版年：2014
- 出版时间：June 2014
- 年：2014
- 卷：53
- 期：4
- 页码：1123-1134
- 全文大小：
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Lars Rejnmark (1)
Carsten Carlberg (2)
Ursula Schwab (3)
Marjukka Kolehmainen (3)
Fredrik Rosqvist (4)
Lieselotte Cloetens (5)
Mona Landin-Olsson (6)
Ingibjorg Gunnarsdottir (7)
Kaisa S. Poutanen (3)
Karl-Heinz Herzig (8) (9)
Ulf Risérus (4)
Markku J. Savolainen (10) (11)
Inga Thorsdottir (7)
Matti Uusitupa (3)
Kjeld Hermansen (1)
1. Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Tage-Hansens Gade 2, 8000, ?rhus C, Denmark
2. Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland
3. Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland
4. Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism, Uppsala University, Uppsala, Sweden
5. Biomedical Nutrition, Pure and Applied Biochemistry, Lund University, Lund, Sweden
6. Department of Endocrinology, Sk?ne University Hospital, Lund, Sweden
7. Unit for Nutrition Research, Landspitali - The National University of Iceland, Faculty of Food Science and Nutrition, School of Health Sciences, University of Iceland, Reykjavík, Iceland
8. Department of Physiology and Biocenter of Oulu, Institute of Biomedicine, Oulu University, Oulu, Finland
9. Medical Research Centre Oulu, Oulu University Hospital, Oulu, Finland
10. Department of Internal Medicine and Biocenter, Institute of Clinical Medicine, University of Oulu, Oulu, Finland
11. Clinical Research Centre, Oulu University Hospital, Oulu, Finland - ISSN：1436-6215
文摘
Purpose At northern latitudes, vitamin D is not synthesized endogenously during winter, causing low plasma 25-hydroxyvitamin D (25(OH)D) concentrations. Therefore, we evaluated the effects of a healthy Nordic diet based on Nordic nutrition recommendations (NNR) on plasma 25(OH)D and explored its dietary predictors. Methods In a Nordic multi-centre trial, subjects (n?=?213) with metabolic syndrome were randomized to a control or a healthy Nordic diet favouring fish (?00?g/week, including ?00?g/week fatty fish), whole-grain products, berries, fruits, vegetables, rapeseed oil and low-fat dairy products. Plasma 25(OH)D and parathyroid hormone were analysed before and after 18- to 24-week intervention. Results At baseline, 45?% had vitamin D inadequacy (<50?nmol/l), whereas 8?% had deficiency (<25?nmol/l). Dietary vitamin D intake was increased by the healthy Nordic diet (P?<?0.001). The healthy Nordic and the control diet reduced the prevalence of vitamin D inadequacy by 42?% (P?<?0.001) and 19?% (P?=?0.002), respectively, without between-group difference (P?=?0.142). Compared with control, plasma 25(OH)D (P?=?0.208) and parathyroid hormone (P?=?0.207) were not altered by the healthy Nordic diet. Predictors for 25(OH)D were intake of vitamin D, eicosapentaenoic acids (EPA), docosahexaenoic acids (DHA), vitamin D supplement, plasma EPA and plasma DHA. Nevertheless, only vitamin D intake and season predicted the 25(OH)D changes. Conclusion Consuming a healthy Nordic diet based on NNR increased vitamin D intake but not plasma 25(OH)D concentration. The reason why fish consumption did not improve vitamin D status might be that many fish are farmed and might contain little vitamin D or that frying fish may result in vitamin D extraction. Additional ways to improve vitamin D status in Nordic countries may be needed.