HPV-16 impairs the subcellular distribution and levels of expression of protein phosphatase 1γ in cervical malignancy
详细信息 查看全文
- 作者：Takayuki Seiki ; Kazunori Nagasaka ; Christian Kranjec ; Kei Kawana…
- 关键词：Cervical cancer ; Immunohistochemistry ; hScrib ; Protein phosphatase 1 ; Proteasome degradation ; Human papillomavirus 16
- 刊名：BMC Cancer
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：15
- 期：1
- 全文大小：1,426 KB
- 刊物主题：Cancer Research; Oncology; Stem Cells; Animal Models; Internal Medicine;
- 出版者：BioMed Central
- ISSN：1471-2407
文摘
Background The high risk Human Papillomavirus (HPV) E6 oncoproteins play an essential role in the development of cervical malignancy. Important cellular targets of E6 include p53 and the PDZ domain containing substrates such as hScrib and Dlg. We recently showed that hScrib activity was mediated in part through recruitment of protein phosphatase 1γ (PP1γ).