From Protecting the Heart to Improving Athletic Performance -the Benefits of Local and Remote Ischaemic Preconditioning

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• 作者：Vikram Sharma ; Reuben Marsh ; Brian Cunniffe…
• 关键词：Remote ischemic preconditioning ; Exercise performance ; Sports ; Cardioprotection ; Ischemia ; reperfusion injury ; CABG ; PCI ; Perconditioning ; Postconditioning ; Acute kidney injury
• 刊名：Cardiovascular Drugs and Therapy
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：29
• 期：6
• 页码：573-588
• 全文大小：564 KB
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• 作者单位：Vikram Sharma (1) (2)
  Reuben Marsh (2)
  Brian Cunniffe (3) (4)
  Marco Cardinale (4) (5)
  Derek M. Yellon (2)
  Sean M. Davidson (2)
  
  1. Department of Internal Medicine, Cleveland Clinic, Cleveland, OH, USA
  2. The Hatter Cardiovascular Institute, University College London, 67 Chenies Mews, London, WC1E 6HX, UK
  3. English institute of Sport, Bisham, Marlow, UK
  4. Institute of Sport, Exercise and Health, UCL, London, UK
  5. Aspire Academy, Doha, Qatar
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Cardiology
  
• 出版者：Springer Netherlands
• ISSN：1573-7241

文摘

Remote Ischemic Preconditioning (RIPC) is a non-invasive cardioprotective intervention that involves brief cycles of limb ischemia and reperfusion. This is typically delivered by inflating and deflating a blood pressure cuff on one or more limb(s) for several cycles, each inflation-deflation being 3- min in duration. RIPC has shown potential for protecting the heart and other organs from injury due to lethal ischemia and reperfusion injury, in a variety of clinical settings. The mechanisms underlying RIPC are under intense investigation but are just beginning to be deciphered. Emerging evidence suggests that RIPC has the potential to improve exercise performance, via both local and remote mechanisms. This review discusses the clinical studies that have investigated the role of RIPC in cardioprotection as well as those studying its applicability in improving athletic performance, while examining the potential mechanisms involved. Keywords Remote ischemic preconditioning Exercise performance Sports Cardioprotection Ischemia-reperfusion injury CABG PCI Perconditioning Postconditioning Acute kidney injury