DynaDom: structure-based prediction of T cell receptor inter-domain and T cell receptor-peptide-MHC (class I) association angles
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- 作者：Thomas Hoffmann ; Antoine Marion ; Iris Antes
- 关键词：T ; cell recognition ; TCR structural modeling ; Epitope prediction ; Glutamine side chain prediction ; Protein domain association angles ; Immunoinformatics ; Adoptive T ; cell therapy ; Vaccine design
- 刊名：BMC Structural Biology
- 出版年：2018
- 出版时间：January 2018
- 年：0
- 卷：17
- 期：1
- 全文大小：3690KB
- 刊物主题：Biochemistry, general; Protein Science; Crystallography and Scattering Methods; Mass Spectrometry; Spectroscopy/Spectrometry;
- 出版者：BioMed Central
- ISSN：1472-6807
- 卷排序：17
文摘
BackgroundT cell receptor (TCR) molecules are involved in the adaptive immune response as they distinguish between self- and foreign-peptides, presented in major histocompatibility complex molecules (pMHC). Former studies showed that the association angles of the TCR variable domains (Vα/Vβ) can differ significantly and change upon binding to the pMHC complex. These changes can be described as a rotation of the domains around a general Center of Rotation, characterized by the interaction of two highly conserved glutamine residues.