A Generic Multi-Compartmental CNS Distribution Model Structure for 9 Drugs Allows Prediction of Human Brain Target Site Concentrations
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- 作者：Yumi Yamamoto ; Pyry A. Välitalo ; Dirk-Jan van den Berg…
- 关键词：KEY WORDSblood ; brain barrier ; central nervous system (CNS) ; human prediction ; pharmacokinetics ; translational model
- 刊名：Pharmaceutical Research
- 出版年：2017
- 出版时间：February 2017
- 年：2017
- 卷：34
- 期：2
- 页码：333-351
- 全文大小：1818KB
- 刊物类别：Biomedical and Life Sciences
- 刊物主题：Pharmacology/Toxicology; Pharmacy; Biochemistry, general; Medical Law; Biomedical Engineering;
- 出版者：Springer US
- ISSN：1573-904X
- 卷排序：34
文摘
PurposePredicting target site drug concentration in the brain is of key importance for the successful development of drugs acting on the central nervous system. We propose a generic mathematical model to describe the pharmacokinetics in brain compartments, and apply this model to predict human brain disposition.