Molecular and Functional Diagnostic Tools in Precision Oncology for Urological Malignancies

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• 作者：Vasanthakumar Sekar ; Debapriya Ghosh Mehrotra…
• 关键词：Urological cancer ; Precision therapy ; Prediction biomarkers ; Ex vivo models
• 刊名：Indian Journal of Surgical Oncology
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：8
• 期：1
• 页码：24-32
• 全文大小：
• 刊物主题：Surgical Oncology; Oncology; Surgery;
• 出版者：Springer India
• ISSN：0976-6952
• 卷排序：8

文摘

Urological malignancies, represented mainly by prostate, bladder, and renal cancers, are some of the leading causes of cancer-related mortalities worldwide. Despite various efforts over decades to develop early detection tests and effective therapeutic paradigms, the response rate to the existing treatments remains low for both primary and late stage/recurrent phases of these cancers. The evolving landscape of molecular diagnostics, aiming to make the diagnosis and treatment more patient-driven, underpins precision oncology and particularly intends to rationally profile individual tumors and highlight the mechanistic insight and complexity of tumor microenvironment in order to develop biomarkers of toxicity risks and response prediction in a clinically oriented dynamical setting. The present review is an effort to capture some of the recent developments in the area of molecular diagnostics and functional testing platforms and their potential application in clinical decision making in the premises of precision oncology of urological malignancies.