Combining PARP inhibitors with radiation therapy for the treatment of glioblastoma: Is PTEN predictive of response?

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• 作者：A. Lester ; R. Rapkins ; S. Nixdorf ; M. Khasraw…
• 关键词：PARP inhibitor ; Glioblastoma ; Biomarkers ; PTEN
• 刊名：Clinical and Translational Oncology
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：19
• 期：3
• 页码：273-278
• 全文大小：
• 刊物主题：Oncology;
• 出版者：Springer International Publishing
• ISSN：1699-3055
• 卷排序：19

文摘

Glioblastoma (GBM) is fatal. The standard radiotherapy and chemotherapy (temozolomide) followed by an adjuvant phase of temozolomide provide patients with, on average, a 2.5 months benefit. New treatments that can improve sensitivity to the standard treatment are urgently needed. Herein, we review the mechanisms and utility of poly (ADP-ribose) polymerase inhibitors in combination with radiation therapy as a treatment option for GBM patients and the role of phosphatase and tensin homologue mutations as a biomarker of response.