Feasibility of baseline neurocognitive assessment using Cogstate during the first month of therapy for childhood leukemia
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- 作者：Stephen A. Sands ; Brian T. Harel ; Mirko Savone ; Kara Kelly…
- 关键词：Neurocognitive ; Acute lymphoblastic leukemia ; Neurotoxicity ; Methotrexate ; Late effects ; Biomarkers
- 刊名：Supportive Care in Cancer
- 出版年：2017
- 出版时间：February 2017
- 年：2017
- 卷：25
- 期：2
- 页码：449-457
- 全文大小：
- 刊物类别：Medicine
- 刊物主题：Oncology; Nursing; Nursing Research; Pain Medicine; Rehabilitation Medicine;
- 出版者：Springer Berlin Heidelberg
- ISSN：1433-7339
- 卷排序：25
文摘
PurposeNeurocognitive impairment is frequently observed among acute lymphoblastic leukemia (ALL) survivors within the domains of intelligence, attention, processing speed, working memory, learning, and memory. However, few have investigated treatment-induced changes in neurocognitive function during the first months of treatment. Additionally, dysfunction during treatment may be preceded by changes in biomarkers measured within cerebrospinal fluid (CSF). Identification of acute declines in neurocognitive function, as well as predictive genotypes or biomarkers, could guide therapeutic trials of protective interventions.