Antidiabetic potential of Rourea minor (Gaertn.) root in streptozotocin—induced diabetic rats
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- 作者：Preeti Kulkarni (1)
Vishal Patel (1)
S. T. Shukla (1)
Ankur Patel (1)
Venkatrao Kulkarni (1) - 关键词：Diabetes mellitus ; Rourea minor ; Streptozotocin ; Hyperglycemia ; Serum glucose
- 刊名：Oriental Pharmacy and Experimental Medicine
- 出版年：2014
- 出版时间：March 2014
- 年：2014
- 卷：14
- 期：1
- 页码：69-76
- 全文大小：469 KB
- 参考文献：1. Abdel-Barry JA, Abdel-Hassan IA, Al-Hakiem MH (1997) Hypoglycemic and antihyperglycemic effects of Trigonnella foenum-graecum leaf in normal and alloxan induced diabetic rats. J Ethnopharmacol 58(3):149-55 CrossRef
2. Ananthan R, Latha M, Ramkumar KM, Pari L, Baskar C, Narmatha V (2004) Modulatory effects of Gymnema montanum leaf extract on alloxan induced oxidative stress in wistar rats. Nutrition 20(3):280-85 CrossRef
3. Aslan M, Orhan DD, Orhan N, Sezik E, Yesilada E (2007) In vivo antidiabetic and antioxidant potential of Helichrysum plicatum ssp. plicatum capitulums in streptozotocin induced-diabetic rats. J Ethnopharmacol 109(1):54-9 CrossRef
4. Berson SA, Yalow RS (1963) Antigens in insulin determinants of specificity of porcine insulin in man. Science 139:844-45 CrossRef
5. Chakrabarti S, Biswas TK, Rokeya B, Ali L, Mosihuzzaman M, Nahar N, Khan AK, Mukherjee B (2003) Advanced studies on the hypoglycemic effect of / Caesalpinia bonducella F. in type 1 and 2 diabetes in Long Evans rats. J Ethnopharmacol 84(1):41-6 CrossRef
6. Chan PK, Hayes AW (1994) Acute toxicity and eye irritancy. Principles and methods of toxicology, 3rd edn. Raven Press Ltd., NY
7. Eddouksa M, Lemhadri A, Zeggwagh NA, Michel JB (2005) Potent hypoglycaemic activity of the aqueous extract of Chamaemelum nobile in normal and streptozotocin-induced diabetic rats. Diabetes Res Clin Pract 67(3):189-95 CrossRef
8. Friedewald WT, Levy RI, Fredrickson DS (1972) Estimation of low-density lipoprotein cholesterol in plasma, without use of the preparative centrifuge. Clin Chem 18:499-02
9. Geoffey VG, Pickup JC (1991) William’s “Text book of diabetes- 2nd edn. Blackwell Scientific Publications, Hoboken, pp 37-4
10. Gerich JE (2003) Clinical significance: pathogenesis and management of postprandial hyperglycemia. Arch Intern Med 163(11):1306-316 CrossRef
11. Ghosh MN (2008) Toxicity studies. In: Fundamentals of experimental pharmacology. Hilton & Company, Kolkata, p 176
12. Goldberg RB (1981) Lipid disorders in diabetes. Diabetes Care 4(5):561-72 CrossRef
13. Kecskemeti V, Bagi Z, Pacher P, Posa I, Kocsis E, Koltai MZ (2002) New trends in the development of oral antidiabetic drugs. Curr Med Chem 9(1):53-1 CrossRef
14. Maiti R, Das UK, Ghosh D (2005) Attenuation of hyperglycemia and hyperlipidemia in streptozotocin-induced diabetic rats by aqueous extract of seed of Tamarindus indica. Biol Pharm Bull 28(7):1172-176 CrossRef
15. Maiti A, Dewanjee S, Jana G, Mandal SC (2008) Hypoglycemic effect of Swietenia macrophylla seeds against type II diabetes. Int J Green Pharm 2(4):224-27 CrossRef
16. Muruganandan S, Srinivasan K, Gupta S, Gupta PK, Lal J (2005) Effect of mangiferin on hyperglycemia and atherogenicity in Streptozotocin-diabetic rats. J Ethnopharmacol 97(3):497-01 CrossRef
17. Orhan N, Aslan M, Orhan DD, Ergun F, Yesilada E (2006) In vivo assessment of antidiabetic and antioxidant activities of antidiabetic and antioxidant activities of Grapevine leaves (Vitis Vinifera) in diabetic rats. J Ethnopharmacol 108(2):280-86 CrossRef
18. Palsamy P, Subramanian S (2008) Resveratrol, a natural phytoalexin, normalizes hyperglycemia in streptozotocin-nicotinamide induced experimental diabetic rats. Biomed Pharmacother 62:598-05 CrossRef
19. Papaccio G, Pisanti FA, Latronico MV, Ammendola E, Galdieri M (2000) Multiple low dose and single high dose treatments with streptozotocin do not generate nitric oxide. J Cell Biochem 77(1):82-1 CrossRef
20. Pathak RM, Ansari S, Mahmood A (1981) Changes in chemical composition of intestinal brush border membrane in alloxan induced chronic diabetes. Indian J Exp Biol 19:503-05
21. Ronald KC, Gordon WC, George KL, Alan JM, Alan MC, Smith R (1994) Joslin’s diabetes mellitus, 13th edn. B.I. Waverly Pvt. Ltd, New Delhi, pp 193-65
22. Sabu MC, Subburaju T (2002) Effect of Cassia auriculata Linn. on serum glucose level, glucose utilization by isolated rat hemidiaphragm. J Ethnopharmacol 80(2-):203-06 CrossRef
23. Schuster DP, Duvuuri V (2002) Diabetes mellitus. Clin Podiatr Med Surg 19(1):79-07 CrossRef
24. Shirwaikar A, Rajendran K, Dinesh Kumar C (2004) Oral antidiabetic activity of Annona squamosa leaf alcohol extract in NIDDM rats. Pharm Biol 42(1):30-5 CrossRef
25. Suzuki M, Nomura C, Odaka H, Ikeda H (1997) Effect of an insulin sensitizer, pioglitazone on hypertension in fructose drinking rats. Jpn J Pharmacol 74(4):297-02 CrossRef
26. Venkatesh S, Reddy GD, Reddy BM, Ramesh M, Rao AV (2003) Antihyperglycemic activity of Carulluma attenuata. Filoterapia 74(3):274-79 CrossRef
27. Yoganarasimhan SN (1996) Medicinal plants of India, vol 1. Karnataka Interline Publishing Pvt. Ltd, Bangalore, pp 404-05 - 作者单位：Preeti Kulkarni (1)
Vishal Patel (1)
S. T. Shukla (1)
Ankur Patel (1)
Venkatrao Kulkarni (1)
1. Department of Pharmacology, Soniya Education Trust’s College of Pharmacy, Dharwad, Karnataka, India - ISSN：2211-1069
文摘
The present investigation aims to examine the antihyperglycemic potential of Rourea minor (Gaertn.) root in normal and streptozotocin (STZ) induced diabetic rats. The root of Rourea minor (Gaertn.) was extracted using ethanol and water and tested for acute toxicity by up and down staircase method. The aqueous Rourea minor (Gaertn.) water (RMW) extract and ethanolic Rourea minor (Gaertn.) extract (RME) at 200 and 400?mg/kg bodyweight doses were screened for blood glucose lowering capacity in normal and STZ induced diabetic animals; the blood samples were collected from the retro orbital plexus and analyzed for serum glucose (SG) level. Glibenclamide (GLB) was used as a standard. The oral glucose tolerance test (OGTT) was carried out in normal as well as STZ induced diabetic rats whereas, insulin tolerance test was carried out in diabetic rats. At the end of 15?days treatment, serum triglyceride (STG), total cholesterol (STC) and HDL-cholesterol (HDL-c) were assayed by auto analyzer. The results of acute toxicity showed that the animals had good tolerance to single doses of RME/RMW (as high as 3?g/kg) and were non-lethal. The glucose tolerance test in normal rats showed that treatment of RME, RMW (both 400?mg/kg), RME (200?mg/kg) and GLB (0.5?mg/kg) exhibited significant reduction (p-lt;-.001) in SG level over a period of 120?min of oral administration of root extract. After 15?days of daily oral administration of the extracts to STZ induced diabetic rats, higher dose of RME could reduce hyperglycemia to an extent of maximum 43.14?%. Also the ethanolic extract was more effective in reducing the SG level (OGTT in STZ induced diabetic rats) with improved glucose tolerance compared to an aqueous extract. Both the doses of RME and RMW exhibited significant reduction (P-lt;-.001) in all tested lipid parameters as compared to diabetic control rats and restored them to nearly-normal values.