Preoperative Treatment Planning Method for Magnetically Induced Hyperthermia Using Thermoseeds
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- 作者：Heng Wang ; Jianan Wu ; Xianwen Zhang ; Ye Liu…
- 关键词：Preoperative planning ; Ferromagnetic thermoseeds ; Magnetically induced hyperthermia ; Temperature field distribution ; Necrosis zone
- 刊名：Journal of Medical and Biological Engineering
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：36
- 期：5
- 页码：726-732
- 全文大小：854 KB
- 刊物类别：Biomedical Engineering; Cell Biology; Imaging / Radiology;
- 刊物主题：Biomedical Engineering; Cell Biology; Imaging / Radiology;
- 出版者：Springer Berlin Heidelberg
- ISSN：2199-4757
- 卷排序：36
文摘
This paper proposes a preoperative planning method for magnetically induced hyperthermia (MIH) using ferromagnetic thermoseeds based on clinical computed tomography images. Combined with external alternating magnetic field excitation, the heating model of millimeter-sized cylindrical thermoseeds and the three-dimensional (3D) tissue bio-heat conduction model are established. The Arrhenius model is employed to evaluate the thermal injury degree of tumors and surrounding normal tissues. Based on these methods, MIH treatment planning system software is developed, where the 3D real-time model of patient anatomy is reconstructed with graphics processing unit-accelerated visualization techniques, organs and tumors are segmented, and thermoseeds are conformal-implanted to establish the temperature field distribution and the necrosis zone. This paper can provide guidance on establishment of a rational MIH preoperative planning to prediction and control of the effective therapeutic region.