Low serum vitamin D level is associated with high risk of metabolic syndrome in post-menopausal women

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• 作者：H. R. Song ; C. H. Park MD ; MSc
• 关键词：Abdominal obesity ; hypertension ; impaired fasting glucose ; metabolic syndrome ; vitamin D
• 刊名：Journal of Endocrinological Investigation
• 出版年：2013
• 出版时间：November 2013
• 年：2013
• 卷：36
• 期：10
• 页码：791-796
• 全文大小：
• 参考文献：1.Holick MF. Vitamin D deficiency. N Engl J Med 2007, 357: 266鈥?1.PubMed CrossRef
  2.Zeitz U, Weber K, Soegiarto DW, Wolf E, Balling R, Erben RG. Impaired insulin secretory capacity in mice lacking a functional vitamin D receptor. FASEB J 2003, 17: 509鈥?1.PubMed
  3.Simpson RU, Thomas GA, Arnold AJ. Identification of 1,25-dihydroxyvitamin D3 receptors and activities in muscle. J Biol Chem 1985, 260: 8882鈥?1.PubMed
  4.Pinelli NR, Jaber LA, Brown MB, Herman WH. Serum 25-hydroxy vitamin d and insulin resistance, metabolic syndrome, and glucose intolerance among Arab Americans. Diabetes Care 2010, 33: 1373鈥?.PubMed Central PubMed CrossRef
  5.Mattila C, Knekt P, M盲nnist枚 S, et al. Serum 25-hydroxyvitamin D concentration and subsequent risk of type 2 diabetes. Diabetes Care 2007, 30: 2569鈥?0.PubMed CrossRef
  6.Choi HS, Kim KA, Lim CY, et al. Low serum vitamin D is associated with high risk of diabetes in Korean adults. J Nutr 2011, 141: 1524鈥?.PubMed CrossRef
  7.Wilson PW, Garrison RJ, Castelli WP, Feinleib M, McNamara PM, Kannel WB. Prevalence of coronary heart disease in the Framingham Offspring Study: role of lipoprotein cholesterols. Am J Cardiol 1980, 46: 649鈥?4.PubMed CrossRef
  8.The Lipid Research Clinics Coronary Primary Prevention Trial results. I. Reduction in incidence of coronary heart disease. JAMA 1984, 251: 351鈥?4.CrossRef
  9.He J, Gu D, Wu X, et al. Major causes of death among men and women in China. N Engl J Med 2005, 353: 1124鈥?4.PubMed CrossRef
  10.Reddy KS. Cardiovascular disease in non-Western countries. N Engl J Med 2004, 350: 2438鈥?0.PubMed CrossRef
  11.Mosekilde L. Vitamin D and the elderly. Clin Endocrinol (Oxf) 2005, 62: 265鈥?1.CrossRef
  12.Alberti KG, Eckel RH, Grundy SM, et al. Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation 2009, 120: 1640鈥?.PubMed CrossRef
  13.Lee SY, Park HS, Kim DJ, et al. Appropriate waist circumference cutoff points for central obesity in Korean adults. Diabetes Res Clin Pract 2007, 75: 72鈥?0.PubMed CrossRef
  14.Park HS, Park CY, Oh SW, Yoo HJ. Prevalence of obesity and metabolic syndrome in Korean adults. Obes Rev 2008, 9: 104鈥?.PubMed CrossRef
  15.Bischoff-Ferrari HA, Giovannucci E, Willett WC, Dietrich T, Dawson-Hughes B. Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes. Am J Clin Nutr 2006, 84: 18鈥?8.PubMed
  16.Choi HS, Oh HJ, Choi H, et al. Vitamin D insufficiency in Korea鈥攁 greater threat to younger generation: the Korea National Health and Nutrition Examination Survey (KNHANES) 2008. J Clin Endocrinol Metab 2011, 96: 643鈥?1.PubMed CrossRef
  17.Ford ES, Ajani UA, McGuire LC, Liu S. Concentrations of serum vitamin D and the metabolic syndrome among U.S. adults. Diabetes Care 2005, 28: 1228鈥?0.PubMed CrossRef
  18.Hypponen E, Boucher BJ, Berry DJ, Power C. 25-hydroxyvitamin D, IGF-1, and metabolic syndrome at 45 years of age: a cross-sectional study in the 1958 British Birth Cohort. Diabetes 2008, 57: 298鈥?05.PubMed CrossRef
  19.Cheng S, Massaro JM, Fox CS, et al. Adiposity, cardiometabolic risk, and vitamin D status: the Framingham Heart Study. Diabetes 2010, 59: 242鈥?.PubMed Central PubMed CrossRef
  20.Chiu KC, Chu A, Go VL, Saad MF. Hypovitaminosis D is associated with insulin resistance and beta cell dysfunction. Am J Clin Nutr 2004, 79: 820鈥?.PubMed
  21.Lu L, Yu Z, Pan A, et al. Plasma 25-hydroxyvitamin D concentration and metabolic syndrome among middle-aged and elderly Chinese individuals. Diabetes Care 2009, 32: 1278鈥?3.PubMed Central PubMed CrossRef
  22.Moy FM, Bulgiba A. High prevalence of vitamin D insufficiency and its association with obesity and metabolic syndrome among Malay adults in Kuala Lumpur, Malaysia. BMC Public Health 2011, 11: 735.PubMed Central PubMed CrossRef
  23.Rueda S, Fernandez-Fernandez C, Romero F, Martinez de Osaba J, Vidal J. Vitamin D, PTH, and the metabolic syndrome in severely obese subjects. Obes Surg 2008, 18: 151鈥?.PubMed CrossRef
  24.Reis JP, von Muhlen D, Kritz-Silverstein D, Wingard DL, Barrett-Connor E. Vitamin D, parathyroid hormone levels, and the prevalence of metabolic syndrome in community-dwelling older adults. Diabetes Care 2007, 30: 1549鈥?5.PubMed CrossRef
  25.Looker AC. Body fat and vitamin D status in black versus white women. J Clin Endocrinol Metab 2005, 90: 635鈥?0.PubMed CrossRef
  26.Awumey EM, Mitra DA, Hollis BW, Kumar R, Bell NH. Vitamin D metabolism is altered in Asian Indians in the southern United States: a clinical research center study. J Clin Endocrinol Metab 1998, 83: 169鈥?3.PubMed
  27.Bland R, Markovic D, Hills CE, et al. Expression of 25-hydroxyvitamin D3-1alpha-hydroxylase in pancreatic islets. J Steroid Biochem Mol Biol 2004, 89-90: 121鈥?.PubMed CrossRef
  28.Pittas AG, Lau J, Hu FB, Dawson-Hughes B. The role of vitamin D and calcium in type 2 diabetes. A systematic review and meta-analysis. J Clin Endocrinol Metab 2007, 92: 2017鈥?9.PubMed Central PubMed CrossRef
  29.Ginsberg HN, Zhang YL, Hernandez-Ono A. Regulation of plasma triglycerides in insulin resistance and diabetes. Arch Med Res 2005, 36: 232鈥?0.PubMed CrossRef
  30.Kim MK, Il Kang M, Won Oh K, et al. The association of serum vitamin D level with presence of metabolic syndrome and hypertension in middle-aged Korean subjects. Clin Endocrinol (Oxf) 2010, 73: 330鈥?.CrossRef
  31.Burgess ED, Hawkins RG, Watanabe M. Interaction of 1,25-dihydroxyvitamin D and plasma renin activity in high renin essential hypertension. Am J Hypertens 1990, 3: 903鈥?.PubMed
  32.Li YC, Kong J, Wei M, Chen ZF, Liu SQ, Cao LP. 1,25-Dihydroxyvitamin D(3) is a negative endocrine regulator of the renin-angiotensin system. J Clin Invest 2002, 110: 229鈥?8.PubMed Central PubMed CrossRef
  33.Duque G, El Abdaimi K, Macoritto M, Miller MM, Kremer R. Estrogens (E2) regulate expression and response of 1,25-dihydroxyvitamin D3 receptors in bone cells: changes with aging and hormone deprivation. Biochem Biophys Res Commun 2002, 299: 446鈥?4.PubMed CrossRef
  34.Pattanaungkul S, Riggs BL, Yergey AL, Vieira NE, O鈥橣allon WM, Khosla S. Relationship of intestinal calcium absorption to 1,25-dihydroxyvitamin D [1,25(OH)2D] levels in young versus elderly women: evidence for age-related intestinal resistance to 1,25(OH)2D action. J Clin Endocrinol Metab 2000, 85: 4023鈥?.PubMed
  35.Scopacasa F, Wishart JM, Horowitz M, Morris HA, Need AG. Relation between calcium absorption and serum calcitriol in normal men: evidence for age-related intestinal resistance to calcitriol. Eur J Clin Nutr 2004, 58: 264鈥?.PubMed CrossRef
  36.Dusso AS. Vitamin D receptor: mechanisms for vitamin D resistance in renal failure. Kidney Int Suppl 2003, 85: S6鈥?.PubMed CrossRef
  37.Marjani A, Moghasemi S. Serum vitamin D and metabolic syndrome among postmenopausal women in Gorgan. Biomed Res 2012, 23: 275鈥?0.
  38.Reis JP, von M眉hlen D, Miller ER 3rd. Relation of 25-hydroxyvitamin D and parathyroid hormone levels with metabolic syndrome among US adults. Eur J Endocrinol 2008, 159: 41鈥?.PubMed CrossRef
  
• 作者单位：H. R. Song (1)
  C. H. Park MD, MSc (2) (3)
  
  1. Department of Epidemiology, Graduate School of Public Health, Seoul National University, Seoul, Korea
  2. Department of Preventive Medicine, College of Medicine, Chungbuk National University, Cheongju, Korea
  3. Department of Family Medicine, College of Medicine, Eulji University, Daejeon, Korea
  
• 刊物类别：Medicine/Public Health, general; Endocrinology; Metabolic Diseases;
• 刊物主题：Medicine/Public Health, general; Endocrinology; Metabolic Diseases;
• 出版者：Springer International Publishing
• ISSN：1720-8386

文摘

Background: Serum vitamin D status, as indicated by 25-(OH)D, is inversely associated with glucose homeostasis, lipid profiles, and blood pressure. Evidence on the association of serum vitamin D with metabolic syndrome (MS) however, is very limited in post-menopausal women. Aim: To investigate the association between serum vitamin D and MS. Material and methods: This study was a cross-sectional study including 778 Korean adults who visited a health promotion center in a university hospital from January 2010 to May 2011. MS was defined according to the American Heart Association/National Heart, Lung, and Blood Institute criteria and the Korean Society for the Study of Obesity. MS and its individual components were assessed, as well as serum 25-(OH)D levels with a multiple logistic regression analysis. Results: The overall prevalence of the MS in participants of this study was 147 (18.9%). After multiple adjustments, compared with the highest quartile serum 25-(OH)D level group (19.9鈥?5.9 ng/ml), the odds ratio for MS in the lowest level group (4.2鈥?.7 ng/ml) was 2.44 [95% confidence interval (CI)=1.32鈥?.48], in the lower level group (9.8鈥?4.1 ng/ml) was 2.20 (95% CI=1.24鈥?.90), and in the intermediate level group (14.3鈥?9.8 ng/ml) was 1.81 (95% CI=1.02鈥?.20). Among the components of MS, the adjusted odds ratios for having an elevated blood pressure, and high triglyceride level in the lowest level group were 1.81 (95% CI, 1.15鈥?.85), 2.74 (95% CI, 1.64鈥?.57), respectively. Conclusions: We found that a low serum 25-(OH)D level is significantly associated with the presence of MS and some metabolic components, especially the high triglyceride level and blood pressure in post-menopausal women. Key-words Abdominal obesity hypertension impaired fasting glucose metabolic syndrome vitamin D