Realistic Head Model Design and 3D Brain Imaging of NIRS Signals Using Audio Stimuli on Preterm Neonates for Intra-Ventricular Hemorrhage Diagnosis

详细信息    查看全文

• 作者：Marc Fournier (1)
  Mahdi Mahmoudzadeh (1)
  Kamran Kazemi (2)
  Guy Kongolo (1)
  Ghislaine Dehaene-Lambertz (3)
  Reinhard Grebe (1)
  Fabrice Wallois (1)
• 关键词：Head model design – ; 3D brain NIRS optical imaging – ; Hemodynamic response to audio stimuli – ; Neonate IVH diagnosis – ; Functional brain imaging
• 刊名：Lecture Notes in Computer Science
• 出版年：2012
• 出版时间：2012
• 年：2012
• 卷：7512
• 期：1
• 页码：172-179
• 全文大小：3.4 MB
• 参考文献：1. Volpe, J.J.: Brain injury in the premature infant: Neuropathology, clinical aspects, and pathogenesis. Clin. Perinatol. 3, 567–587 (1997)
  2. Ballabh, P.: Intraventricular hemorrhage in premature infants: mechanism of disease. Pediatr. Res. 67, 1–8 (2010)
  3. Gibson, A.P., Hebden, J.C., Arridge, S.R.: Recent advances in diffuse optical imaging. Phys. Med. Biol. 50, 1–43 (2005)
  4. Hoshi, Y., Kohri, S., Matsumoto, Y., Cho, K., Matsuda, T., Okajima, S., Fujimoto, S.: Hemodynamic responses to photic stimulation in neonates. Pediatr. Neurol. 23, 323–327 (2000)
  5. Sakatani, K., Chen, S., Lichty, W., Zuo, H., Wang, Y.P.: Cerebral blood oxygenation changes induced by auditory stimulation in newborn infants measured by near infrared spectroscopy. Early Hum. Dev. 55, 229–236 (1999)
  6. Dehghani, H., White, B.R., Zeff, B.W., Tizzard, A., Culver, J.P.: Depth sensitivity and image reconstruction analysis of dense imaging arrays for mapping brain function with diffuse optical tomography. Applied Optics 48, D137–D143 (2009)
  7. Meek, J.H., Tyszczuk, L., Elwell, C.E., Wyatt, J.S.: Low cerebral blood flow is a risk factor for severe intraventricular haemorrhage. Arch. Dis. Child Fetal Neonatal Ed. 81, 15–18 (1999)
  8. Downie, A.L., Frisk, V., Jakobson, L.S.: The impact of periventricular brain injury on reading and spelling abilities in the late elementary and adolescent years. Child Neuropsychol. 11, 479–495 (2005)
  9. Dehaene-Lambertz, G.: Cerebral specialization for speech and non-speech stimuli in infants. J. Cogn. Neurosci. 12, 449–460 (2000)
  10. Delpy, D.T., Cope, M., Van-Der-Zee, P., Arridge, S., Wray, S., Wyatt, J.: Estimation of optical pathlength through tissue from direct time of flight measurement. Phys. Med. Biol. 33, 1433–1442 (1988)
  11. Murgasova, M., Aljabar, P., Srinivasan, L., Counsell, S.J., Doria, V., Serag, A., Gousias, I.S., Boardman, J.P., Rutherford, M.A., Edwards, A.D., Hajnal, J.V., Rueckert, D.: A dynamic 4D probabilistic atlas of the developing brain. Neuroimage 54, 2750–2763 (2011)
  12. Jafarian, N., Kazemi, K., Abrishami-Moghaddam, H., Grebe, R., Fournier, M., Helfroush, M.S., Gondry-Jouet, C., Wallois, F.: Automatic segmentation of newborns’ skull and fontanel from CT data using model-based variational level set. Signal Image and Video Processing (to appear, 2012), doi:10.1007/s11760-012-0300-x
  13. Ashburner, J., Friston, K.J.: Unified segmentation. Neuroimage 26, 839–851 (2005)
  14. Chan, T.F., Vese, L.A.: Active contours without edges. IEEE Trans. Image Process. 10, 266–277 (2001)
  15. Bunce, S., Izzetoglu, M., Izzetoglu, K., Onaral, B., Pourrezaei, K.: Functional near-infrared spectroscopy: an emerging neuro-imaging modality. Eng. Med. Biol. 25, 54–62 (2006)
  16. Sassaroli, A., Frederick, B., Tong, Y., Renshaw, P.F., Fantini, S.: Spatially weighted BOLD signal for comparison of functional magnetic resonance imaging and near-infrared imaging of the brain. Neuroimage 33, 505–514 (2006)
  17. Dehaes, M., Kazemi, K., Pelegrini-Issac, M., Grebe, R., Benali, H., Wallois, F.: Quantitative effect of the neonatal fontanel on synthetic near infrared spectroscopy measurements. Hum. Brain Mapp. (2011) (to appear), doi:10.1002/hbm.21483
  18. Holm, S.: A simple sequentially rejective multiple test procedure. Scand. J. Statist. 6, 65–70 (1979)
• 作者单位：1. GRAMFC, Inserm U1105, CHU Amiens, University of Picardie Jules Verne, Amiens, France2. Dept. of Electrical and Electronics Engineering, Shiraz University of Technology, Shiraz, Iran3. NeuroSpin, CEA, Inserm U992, Cognitive Neuroimaging, University Paris XI, Paris, France
• ISSN：1611-3349

文摘

In this paper we propose an auditory stimulation and Near Infra-Red Spectroscopy (NIRS) hemodynamic changes acquisition protocol for preterm neonates. This study is designed to assess the specific characteristics of neurovascular coupling to auditory stimuli in healthy and ill neonate brains. The method could lead to clinical application in Intra-Ventricular Hemorrhage (IVH) diagnosis along with other techniques such as EEG. We propose a realistic head model creation with all useful head structures and brain tissues including the neonate fontanel for more accurate results from NIRS signals modeling. We also design a 3D imaging tool for dynamic mapping and analysis of brain activation onto the cortex surface. Results show significant differences in oxy-hemoglobin between healthy neonates and subjects with IVH.