Priapism after tumor necrosis factor alpha inhibitor use
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- 作者：Adam J. Kreitenberg (1)
Elizabeth C. Ortiz (1)
Daniel G. Arkfeld (1)
1. Division of Rheumatology ; Department of Medicine ; Keck School of Medicine at University of Southern California ; Hoffman Medical Research Center ; 2011 Zonal Ave ; HMR 711 ; Los Angeles ; CA ; 90033 ; USA - 关键词：Adverse event ; Priapism ; Rheumatoid arthritis ; Tumor necrosis factor alpha inhibition
- 刊名：Clinical Rheumatology
- 出版年：2015
- 出版时间：April 2015
- 年：2015
- 卷：34
- 期：4
- 页码：801-802
- 全文大小：72 KB
- 参考文献：1. Keller, JJ, Lin, HC (2012) A population-based study on the association between rheumatoid arthritis and erectile dysfunction. Ann Rheum Dis 71: pp. 1102-1103 CrossRef
2. Adalimumab [package insert]. North Chicago: AbbVie Inc.; January 2013
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5. Vlachopoulos, C, Aznaouridis, K, Loakeimidis, N (2006) Unfavourable endothelial and inflammatory state in erectile dysfunction patients with or without coronary artery disease. Eur Heart J 27: pp. 2640-2648 CrossRef
6. Carneiro, FS, Webb, RC, Tostes, RC (2010) Emerging role for TNF-伪 in erectile dysfunction. J Sex Med 7: pp. 3823-3834 CrossRef
7. Oh, JS, Heo, HM, Kim, YG, Lee, SG, Lee, SK, Yoo, B (2009) The effect of anti-tumor necrosis factor agents on sexual dysfunction in male patients with ankylosing spondylitis: a pilot study. Int J Impot Res 21: pp. 372-375 CrossRef - 刊物类别：Medicine
- 刊物主题：Medicine & Public Health
Rheumatology - 出版者：Springer London
- ISSN：1434-9949
文摘
We present a possible important association of tumor necrosis factor-alpha inhibition (TNFa-i) and erectile function in a male patient with rheumatoid arthritis (RA). Long-standing, untreated RA may result in significant physical limitation and disability, however often overlooked is the association between RA and erectile and sexual dysfunction. Ischemic priapism is currently unrecognized as an adverse reaction associated with TNFa-i use and there have been no reported cases with adalimumab. Our patient, a 58-year-old Hispanic man, with sero-positive, erosive RA developed persistent priapism (17 days) despite multiple urologic interventions after initial adalimumab 40 mg administration. TNFa has recently been implicated as a potential factor in erectile dysfunction through its role in vascular reactivity. Excess TNFa, from active RA, may perturb intracavernosal smooth muscle and endothelial cell function; theoretically, TNFa inhibition may then causes excess local nitric oxide production and subsequent priapism. The potential role of TNFa-i in ED and risk for priapism is an important area for future study.