The time course of erythrocyte membrane fatty acid concentrations during and after treatment of non-human primates with increasing doses of an omega-3 rich phospholipid preparation derived from krill-oil

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• 作者：Petter-Arnt Hals ; Xiaoli Wang ; Fabiana Piscitelli…
• 关键词：Phospholipids ; Long ; chain omega ; 3 fatty acids ; EPA ; DHA ; Omega ; 3 index ; Endocannabinoids
• 刊名：Lipids in Health and Disease
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：16
• 期：1
• 全文大小：1335KB
• 刊物主题：Lipidology; Medical Biochemistry; Clinical Nutrition;
• 出版者：BioMed Central
• ISSN：1476-511X
• 卷排序：16

文摘

BackgroundA commonly used measure to reflect the intake of the long-chain omega-3 fatty acids EPA and DHA is the omega-3 index, defined as the sum of EPA + DHA as % of total fatty acids in erythrocyte membrane. When the omega-3 index changes it follows that the relative fractions of other fatty acids in the membrane are also changed. In the present study, increasing doses of a preparation of omega-3 rich phospholipids extracted from krill oil were administered orally to non-human primates for 12 weeks and the time course of EPA, DHA and 22 other fatty acids in erythrocytes was determined bi-weekly during treatment and for 8 weeks after cessation of treatment. Plasma concentrations of six endocannabinoid-type mediators being downstream metabolites of some fatty acids analyzed in erythrocytes were also determined.