PRKCH 1425G/A Polymorphism Predicts Recurrence of Ischemic Stroke in a Chinese Population

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• 作者：Zhizhong Zhang ; Gelin Xu ; Wusheng Zhu ; Liping Cao ; Bernard Yan…
• 关键词：PRKCH ; Polymorphism ; Stroke ; Recurrence
• 刊名：Molecular Neurobiology
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：52
• 期：3
• 页码：1648-1653
• 全文大小：488 KB
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• 作者单位：Zhizhong Zhang (1)
  Gelin Xu (1)
  Wusheng Zhu (1)
  Liping Cao (1)
  Bernard Yan (2)
  Xinfeng Liu (1)
  
  1. Department of Neurology, Jinling Hospital, Nanjing University School of Medicine, 305# East Zhongshan Road, Nanjing, 210002, Jiangsu Province, China
  2. Melbourne Brain Centre, Royal Melbourne Hospital, University of Melbourne, Melbourne, Australia
  
• 刊物主题：Neurosciences; Neurobiology; Cell Biology; Neurology;
• 出版者：Springer US
• ISSN：1559-1182

文摘

A recent genome-wide association study (GWAS) identified a nonsynonymous SNP (1425G/A) in PRKCH which was associated with increased risk of ischemic stroke. The purpose of this study was to examine whether this functional polymorphism is associated with stroke onset and prognosis in a Chinese population. We genotyped PRKCH 1425G/A using Improved Multiple Ligase Detection Reaction in 919 patients with ischemic stroke. Analyses of genotype association with onset and prognosis outcomes were assessed by the Kaplan-Meier method, the log-rank test, and the Cox proportional hazards models. PRKCH 1425G/A was not associated with age of stroke onset (P--.323). However, this functional polymorphism was significantly associated with risk of stroke recurrence in recessive models (hazard ratio [HR]--.23; 95 % confidential interval [CI], 1.06 to 4.68; P--.014), and this effect was more predominant among smokers (HR--.67; 95 % CI, 1.47-.18; P--.005). Moreover, the variant genotypes of PRKCH 1425G/A are an independent prognostic factor for ischemic stroke in the final multivariate Cox regression model. Our findings show that PRKCH 1425G/A may be a useful biomarker for predicting the recurrence of ischemic stroke. Keywords PRKCH Polymorphism Stroke Recurrence