Transcriptional profiling of PRKG2-null growth plate identifies putative down-stream targets of PRKG2
详细信息 查看全文
- 作者：James E Koltes ; Dinesh Kumar ; Ranjit S Kataria ; Vickie Cooper…
- 关键词：Cattle ; cGMP ; dependent ; Type II ; Protein kinase (PRKG2) ; Dwarfism
- 刊名：BMC Research Notes
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：8
- 期：1
- 全文大小：805 KB
- 刊物主题：Biomedicine general; Medicine/Public Health, general; Life Sciences, general;
- 出版者：BioMed Central
- ISSN：1756-0500
文摘
Background Kinase activity of cGMP-dependent, type II, protein kinase (PRKG2) is required for the proliferative to hypertrophic transition of growth plate chondrocytes during endochondral ossification. Loss of PRKG2 function in rodent and bovine models results in dwarfism. The objective of this study was to identify pathways regulated or impacted by PRKG2 loss of function that may be responsible for disproportionate dwarfism at the molecular level.