In Vitro Oxidation of Collagen Promotes the Formation of Advanced Oxidation Protein Products and the Activation of Human Neutrophils

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• 作者：Guilherme Vargas Bochi ; Vanessa Dorneles Torbitz ; Luízi Prestes de Campos…
• 刊名：Inflammation
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：39
• 期：2
• 页码：916-927
• 全文大小：1,007 KB
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• 作者单位：Guilherme Vargas Bochi (1) (2)
  Vanessa Dorneles Torbitz (1) (3)
  Luízi Prestes de Campos (1)
  Manuela Borges Sangoi (1) (3)
  Natieli Flores Fernandes (1)
  Patrícia Gomes (4)
  Maria Beatriz Moretto (2) (3)
  Fernanda Barbisan (5)
  Ivana Beatrice Mânica da Cruz (5)
  Rafael Noal Moresco (1) (2) (3) (6)
  
  1. Laboratory of Clinical Biochemistry, Department of Clinical and Toxicological Analysis, Health Sciences Center, Federal University of Santa Maria, Santa Maria, Brazil
  2. Pharmacology Postgraduate Program, Health Sciences Center, Federal University of Santa Maria, Santa Maria, Brazil
  3. Pharmaceutical Sciences Postgraduate Program, Health Sciences Center, Federal University of Santa Maria, Santa Maria, Brazil
  4. Nanosciences Postgraduate Program, Franciscan University Center, Santa Maria, Brazil
  5. Biogenomic Laboratory, Department of Morphology, Health Science Center, Federal University of Santa Maria, Santa Maria, Brazil
  6. Centro de Ciências da Saúde, Departamento de Análises Clínicas e Toxicológicas, Universidade Federal de Santa Maria, Avenida Roraima 1000, Prédio 26, Sala 1401, Camobi, 97105-900, Santa Maria-RS, Brasil
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Rheumatology
  Internal Medicine
  Pharmacology and Toxicology
  Pathology
  
• 出版者：Springer Netherlands
• ISSN：1573-2576

文摘

The accumulation of advanced oxidation protein products (AOPPs) has been linked to several pathological conditions. Here, we investigated collagen as a potential source for AOPP formation and determined the effects of hypochlorous acid (HOCl)-treated collagen (collagen-AOPPs) on human neutrophil activity. We also assessed whether alpha-tocopherol could counteract these effects. Exposure to HOCl increased the levels of collagen-AOPPs. Collagen-AOPPs also stimulated the production of AOPPs, nitric oxide (NO), superoxide radicals (O₂ −), and HOCl by neutrophils. Collagen-AOPPs induced apoptosis and decreased the number of viable cells. Alpha-tocopherol prevented the formation of collagen-AOPPs, strongly inhibited the collagen-AOPP-induced production of O₂ − and HOCl, and increased the viability of neutrophils. Our results suggest that collagen is an important protein that interacts with HOCl to form AOPPs, and consequently, collagen-AOPP formation is related to human neutrophil activation and cell death.