Natural Products: An Alternative to Conventional Therapy for Dermatophytosis?
详细信息 查看全文
- 作者：Graciliana Lopes ; Eugénia Pinto ; Lígia Salgueiro
- 关键词：Natural products ; Dermatophytosis ; Non ; volatile extracts ; Essential oils
- 刊名：Mycopathologia
- 出版年：2017
- 出版时间：February 2017
- 年：2017
- 卷：182
- 期：1-2
- 页码：143-167
- 全文大小：980KB
- 刊物类别：Biomedical and Life Sciences
- 刊物主题：Microbiology; Medical Microbiology; Eukaryotic Microbiology; Microbial Ecology; Plant Sciences;
- 出版者：Springer Netherlands
- ISSN：1573-0832
- 卷排序：182
文摘
The increased incidence of fungal infections, associated with the widespread use of antifungal drugs, has resulted in the development of resistance, making it necessary to discover new therapeutic alternatives. Among fungal infections, dermatophytoses constitute a serious public health problem, affecting 20–25 % of the world population. Medicinal plants represent an endless source of bioactive molecules, and their volatile and non-volatile extracts are clearly recognized for being the historical basis of therapeutic health care. Because of this, the research on natural products with antifungal activity against dermatophytes has considerably increased in recent years. However, despite the recognized anti-dermatophytic potential of natural products, often advantageous face to commercial drugs, there is still a long way to go until their use in therapeutics. This review attempts to summarize the current status of anti-dermatophytic natural products, focusing on their mechanism of action, the developed pharmaceutical formulations and their effectiveness in human and animal models of infection.