The interaction between vaginal microbiota, cervical length, and vaginal progesterone treatment for preterm birth risk

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• 作者：Lindsay M. Kindinger ; Phillip R. Bennett ; Yun S Lee ; Julian R. Marchesi…
• 关键词：Vaginal microbiome ; Progesterone ; Lactobacillus ; Preterm birth ; Cervical length
• 刊名：Microbiome
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：5
• 期：1
• 全文大小：2316KB
• 刊物主题：Medical Microbiology; Bioinformatics; Microbial Ecology; Microbiology; Microbial Genetics and Genomics; Virology;
• 出版者：BioMed Central
• ISSN：2049-2618
• 卷排序：5

文摘

BackgroundPreterm birth is the primary cause of infant death worldwide. A short cervix in the second trimester of pregnancy is a risk factor for preterm birth. In specific patient cohorts, vaginal progesterone reduces this risk. Using 16S rRNA gene sequencing, we undertook a prospective study in women at risk of preterm birth (n = 161) to assess (1) the relationship between vaginal microbiota and cervical length in the second trimester and preterm birth risk and (2) the impact of vaginal progesterone on vaginal bacterial communities in women with a short cervix.