Elevated collagen-I augments tumor progressive signals, intravasation and metastasis of prolactin-induced estrogen receptor alpha positive mammary tumor cells

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• 作者：Craig E. Barcus ; Kathleen A. O’Leary ; Jennifer L. Brockman…
• 关键词：Tumor microenvironment ; Collagen ; Desmoplasia ; Breast cancer ; Extracellular matrix ; Tumor progression ; Prolactin
• 刊名：Breast Cancer Research
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：19
• 期：1
• 全文大小：5334KB
• 刊物主题：Cancer Research; Oncology; Surgical Oncology;
• 出版者：BioMed Central
• ISSN：1465-542X
• 卷排序：19

文摘

BackgroundThe development and progression of estrogen receptor alpha positive (ERα+) breast cancer has been linked epidemiologically to prolactin. However, activation of the canonical mediator of prolactin, STAT5, is associated with more differentiated cancers and better prognoses. We have reported that density/stiffness of the extracellular matrix potently modulates the repertoire of prolactin signals in human ERα + breast cancer cells in vitro: stiff matrices shift the balance from the Janus kinase (JAK)2/STAT5 cascade toward pro-tumor progressive extracellular regulated kinase (ERK)1/2 signals, driving invasion. However, the consequences for behavior of ERα + cancers in vivo are not known.