CRISPR-Cas-System als molekulare Schere für Gentherapie
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- 作者：Dr. G. A. Heinz ; Dr. M.-F. Mashreghi
- 关键词：SchlüsselwörterCRISPR ; Cas9 ; Immunsystem ; Prokaryoten ; Genom ; Genmutation
- 刊名：Zeitschrift für Rheumatologie
- 出版年：2017
- 出版时间：February 2017
- 年：2017
- 卷：76
- 期：1
- 页码：46-49
- 全文大小：
- 刊物主题：Internal Medicine; Rheumatology;
- 出版者：Springer Medizin
- ISSN：1435-1250
- 卷排序：76
文摘
Since the discovery of the CRISPR-Cas system as the adaptive immune system of prokaryotes, the underlying mechanism has proven to be a precise molecular tool for the targeted editing of genetic information in various cell types. By using the CRISPR-Cas9 system DNA sequences can be cut out at any site in the genome and changed in a sequence-specific manner. In the long term this provides the opportunity to cure diseases caused by gene mutations.