Create, activate, destroy, repeat: Cdk1 controls proliferation by limiting transcription factor activity
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- 作者：Jennifer A. Benanti
- 关键词：Cell cycle ; Gene expression ; Cyclin ; dependent kinase ; Hcm1 ; Calcineurin
- 刊名：Current Genetics
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：62
- 期：2
- 页码：271-276
- 全文大小：879 KB
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1. Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, MA, 01605, USA - 刊物类别：Biomedical and Life Sciences
- 刊物主题：Life Sciences
Microbial Genetics and Genomics
Microbiology
Biochemistry
Cell Biology
Plant Sciences
Proteomics - 出版者：Springer Berlin / Heidelberg
- ISSN：1432-0983
文摘
Progression through the cell cycle is controlled by a network of transcription factors that coordinate gene expression with cell-cycle events. One transcriptional activator in this network in budding yeast is the forkhead protein Hcm1, which controls the expression of genes that are transcribed during S-phase. Hcm1 activity is coordinated with the cell cycle via its regulation by cyclin-dependent kinase (Cdk1), which both activates Hcm1 and targets it for degradation, through phosphorylation of distinct sites. The mechanisms controlling the differential phosphorylation timing of the activating and destabilizing phosphosites are not clear. However, a recent study shows that the phosphatase calcineurin specifically removes activating phosphates from Hcm1 when cells are exposed to environmental stress, thus extinguishing its activity and slowing proliferation under unfavorable growth conditions. This regulatory mechanism, whereby a phosphatase actively alters the distribution of phosphosites on a cell cycle-regulatory transcription factor to elicit a change in cellular proliferation, adds an additional layer of complexity to the regulatory network controlling the cell cycle. Furthermore, this regulatory paradigm is likely to be a conserved mode of phosphoregulation that controls the cell cycle in diverse systems.