Proprioceptive sensitivity in Ehlers–Danlos syndrome patients

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• 作者：Holly A. Clayton ; Erin K. Cressman ; Denise Y. P. Henriques
• 关键词：Proprioception ; Ehlers–Danlos syndrome ; Generalized joint hypermobility ; Reaches ; Multisensory integration
• 刊名：Experimental Brain Research
• 出版年：2013
• 出版时间：October 2013
• 年：2013
• 卷：230
• 期：3
• 页码：311-321
• 全文大小：880KB
• 参考文献：1. Anguera JA, Reuter-Lorenz PA, Willingham DT, Seidler RD (2011) Failure to engage spatial working memory contributes to age-related declines in visuomotor learning. J Cogn Neurosci 23:11-5 CrossRef
  2. Beighton P, de Paepe A, Danks D, Finidori G, Gedde-Dahl T, Goodman R, Hall JG, Hollister DW, Horton W, McKusick VA (1988) International nosology of heritable disorders of connective tissue, Berlin, 1986. Am J Med Genet 29:581-94 CrossRef
  3. Beighton P, De Paepe A, Hall JG, Hollister DW, Pope FM, Pyeritz RE, Steinmann B, Tsipouras P (1992) Molecular nosology of heritable disorders of connective tissue. Am J Med Genet 42:431-48 CrossRef
  4. Beighton P, De Paepe A, Steinmann B, Tsipouras P, Wenstrup RJ (1997) Ehlers–Danlos syndromes: revised nosology, Villefranche, 1997. Ehlers–Danlos National Foundation (USA) and Ehlers–Danlos Support Group (UK). Am J Med Genet 77:31-7
  5. Bernier PM, Chua R, Bard C, Franks IM (2006) Updating of an internal model without proprioception: a deafferentation study. Neuroreport 17:1421-425 CrossRef
  6. Bock O (2005) Components of sensorimotor adaptation in young and elderly subjects. Exp Brain Res 160:259-63 CrossRef
  7. Bock O, Girgenrath M (2006) Relationship between sensorimotor adaptation and cognitive functions in younger and older subjects. Exp Brain Res 169:400-06 CrossRef
  8. Buch ER, Young S, Contreras-Vidal JL (2003) Visuomotor adaptation in normal aging. Learn Mem 10:55-3 CrossRef
  9. Castori M (2012) Ehlers-danlos syndrome, hypermobility type: an underdiagnosed hereditary connective tissue disorder with mucocutaneous, articular, and systemic manifestations. ISRN Derm 2012:1-2 CrossRef
  10. Celletti C, Castori M, Galli M, Rigoldi C, Grammatico P, Albertini G, Camerota F (2011) Evaluation of balance and improvement of proprioception by repetitive muscle vibration in a 15-year-old girl with joint hypermobility syndrome. Arthritis Care Res (Hoboken) 63:775-79 CrossRef
  11. Cressman EK, Henriques DYP (2009) Sensory recalibration of hand position following visuomotor adaptation. J Neurophysiol 102:3505-518 CrossRef
  12. Cressman EK, Salomonczyk D, Henriques DYP (2010) Visuomotor adaptation and proprioceptive recalibration in older adults. Exp Brain Res 205:533-44 CrossRef
  13. De Paepe A, Malfait F (2004) Bleeding and bruising in patients with Ehlers–Danlos syndrome and other collagen vascular disorders. Br J Haematol 127:491-00 CrossRef
  14. Fatoye F, Palmer S, Macmillan F, Rowe P, van der Linden M (2009) Proprioception and muscle torque deficits in children with hypermobility syndrome. Rheumatology (Oxford) 48:152-57 CrossRef
  15. Goble DJ, Coxon JP, Wenderoth N, Van Impe A, Swinnen SP (2009) Proprioceptive sensibility in the elderly: degeneration, functional consequences and plastic-adaptive processes. Neurosci Biobehav Rev 33:271-78 CrossRef
  16. Hall MG, Ferrell WR, Sturrock RD, Hamblen DL, Baxendale RH (1995) The effect of the hypermobility syndrome on knee joint proprioception. Br J Rheumatol 34:121-25 CrossRef
  17. Henriques DY, Soechting JF (2003) Bias and sensitivity in the haptic perception of geometry. Exp Brain Res 150:95-08
  18. Hollister DW (1978) Heritable disorders of connective tissue: Ehlers–Danlos syndrome. Pediatr Clin North Am 25:575-91
  19. Ingram HA, van Donkelaar P, Cole J, Vercher JL, Gauthier GM, Miall RC (2000) The role of proprioception and attention in a visuomotor adaptation task. Exp Brain Res 132:114-26 CrossRef
  20. Izawa J, Criscimagna-Hemminger SE, Shadmehr R (2012) Cerebellar contributions to reach adaptation and learning sensory consequences of action. J Neurosci 32:4230-239 CrossRef
  21. Jeremiah HM, Alexander CM (2010) Do hypermobile subjects without pain have alteration to the feedback mechanisms controlling the shoulder girdle? Musculoskelet Care 8:157-63 CrossRef
  22. Keer R, Grahame R (2003) Hypermobility syndrome: recognition and management for physiotherapists. Butterworth-Heinemann, New York
  23. Kesten H (1958) Accelerated stochastic approximation. Ann Math Stat 29:41-9 CrossRef
  24. Lawrence EJ (2005) The clinical presentation of Ehlers–Danlos syndrome. Adv Neonatal Care 5:301-14 CrossRef
  25. Malfait F, Wenstrup RJ, De Paepe A (2010) Clinical and genetic aspects of Ehlers–Danlos syndrome, classic type. Genet Med 12:597-05 CrossRef
  26. Parapia LA, Jackson C (2008) Ehlers–Danlos syndrome—a historical review. Br J Haematol 141:32-5 CrossRef
  27. Rombaut L, De Paepe A, Malfait F, Cools A, Calders P (2010a) Joint position sense and vibratory perception sense in patients with Ehlers–Danlos syndrome type III (hypermobility type). Clin Rheumatol 29:289-95 CrossRef
  28. Rombaut L, Malfait F, Cools A, De Paepe A, Calders P (2010b) Musculoskeletal complaints, physical activity and health-related quality of life among patients with the Ehlers–Danlos syndrome hypermobility type. Disabil Rehabil 32:1339-345 CrossRef
  29. Sacheti A, Szemere J, Bernstein B, Tafas T, Schechter N, Tsipouras P (1997) Chronic pain is a manifestation of the Ehlers–Danlos syndrome. J Pain Symptom Manag 14:88-3 CrossRef
  30. Sahin N, Baskent A, Cakmak A, Salli A, Ugurlu H, Berker E (2008) Evaluation of knee proprioception and effects of proprioception exercise in patients with benign joint hypermobility syndrome. Rheumatol Int 28:995-000 CrossRef
  31. Salomonczyk D, Cressman EK, Henriques DY (2011) Proprioceptive recalibration following prolonged training and increasing distortions in visuomotor adaptation. Neuropsychologia 49:3053-062 CrossRef
  32. Seidler RD (2006) Differential effects of age on sequence learning and sensorimotor adaptation. Brain Res Bull 70:337-46 CrossRef
  33. Synofzik M, Lindner A, Thier P (2008) The cerebellum updates predictions about the visual consequences of one’s behavior. Curr Biol 18:814-18 CrossRef
  34. Tinkle BT, Bird HA, Grahame R, Lavallee M, Levy HP, Sillence D (2009) The lack of clinical distinction between the hypermobility type of Ehlers–Danlos syndrome and the joint hypermobility syndrome (a.k.a. hypermobility syndrome). Am J Med Genet A 149A:2368-370 CrossRef
  35. Treutwein B (1995) Adaptive psychophysical procedures. Vision Res 35:2503-522
  36. Voermans NC, Knoop H (2011) Both pain and fatigue are important possible determinants of disability in patients with the Ehlers–Danlos syndrome hypermobility type. Disabil Rehabil 33:706-07 CrossRef
  
• 作者单位：Holly A. Clayton (1) (2)
  Erin K. Cressman (3)
  Denise Y. P. Henriques (1) (2) (4)
  
  1. Centre for Vision Research, York University, Toronto, Canada
  2. Department of Psychology, York University, Toronto, Canada
  3. School of Human Kinetics, University of Ottawa, Ottawa, Canada
  4. School of Kinesiology and Health Science, York University, 4700 Keele Street, Toronto, ON, M3J 1P3, Canada
  
• ISSN：1432-1106

文摘

Reaching movements are rapidly adapted following training with rotated visual feedback of the hand. Our laboratory has also found that this visuomotor adaptation results in changes in estimates of felt hand position (proprioceptive recalibration) in the direction of the visuomotor distortion (Cressman and Henriques in J Neurophysiol 102:3505-518, 2009; Cressman et al. in Exp Brain Res 205:533-44, 2010). In the current study, we investigated proprioceptive acuity and proprioceptive recalibration in a group of individuals with Ehlers–Danlos syndrome (EDS), a degenerative condition associated with collagen malformation. Some studies have suggested that these patients may have proprioceptive impairments, but the exact nature of the impairment is unclear (Rombaut et al. in Clin Rheumatol 29:289-95, 2010a). In this study, we measured the ability of EDS patients to estimate their felt hand position and tested whether these estimates changed following visuomotor adaptation. We found EDS patients were less precise in estimating their felt hand position in the peripheral workspace compared to healthy controls. Despite this poorer sensitivity, they recalibrated hand proprioception to the same extent as healthy controls. This is consistent with other populations who experience proprioceptive deficits (e.g. the elderly, Parkinson’s disease patients), suggesting that sensory noise does not influence the extent of either motor or sensory plasticity.