Translationally controlled tumour protein TCTP is induced early in human colorectal tumours and contributes to the resistance of HCT116 colon cancer cells to 5-FU and oxaliplatin
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- 作者：Ulrich-Axel Bommer ; Kara L. Vine ; Prianka Puri…
- 关键词：Translationally controlled tumour protein (TCTP) ; Human colorectal tumours ; HCT116 colon cancer cells ; 5 ; fluorouracil (5 ; FU) ; Oxaliplatin ; PI3 ; kinase/Akt/mTORC1 signalling pathway ; Translational regulation ; Chemoresistance
- 刊名：Cell Communication and Signaling
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：15
- 期：1
- 全文大小：1822KB
- 刊物主题：Cell Biology; Protein-Ligand Interactions; Receptors; Cytokines and Growth Factors;
- 出版者：BioMed Central
- ISSN：1478-811X
- 卷排序：15
文摘
BackgroundTranslationally controlled tumour protein TCTP is an anti-apoptotic protein frequently overexpressed in cancers, where high levels are often associated with poor patient outcome. TCTP may be involved in protecting cancer cells against the cytotoxic action of anti-cancer drugs. Here we study the early increase of TCTP levels in human colorectal cancer (CRC) and the regulation of TCTP expression in HCT116 colon cancer cells, in response to treatment with the anti-cancer drugs 5-FU and oxaliplatin.