Increased expression of Cks1 protein is associated with lymph node metastasis and poor prognosis in nasopharyngeal carcinoma

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• 作者：Lina Xu ; Songqing Fan ; Jin Zhao ; Peng Zhou ; Shuzhou Chu ; Jiadi Luo…
• 关键词：Nasopharyngeal carcinoma (NPC) ; Cyclin ; dependent protein kinase regulatory subunit 1 (CKS1) ; Lymph node metastasis (LNM) ; Prognostic factor
• 刊名：Diagnostic Pathology
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：12
• 期：1
• 全文大小：5967KB
• 刊物主题：Pathology;
• 出版者：BioMed Central
• ISSN：1746-1596
• 卷排序：12

文摘

BackgroundThe Cks1 protein is an essential factor in regulating cell cycle by mediating the ubiquitination of CDK inhibitor p27kip1. It has been reported that aberrant expression of Cks1 and p27kip1 proteins was found in various tumors and related to initiation and progression of carcinomas. However, the potential roles which Cks1 and p27KIP1 proteins play in NPC remain unclear. This study aims to examine the expression status of Cks1 and p27kip1 and their possible prognostic significance in NPC.