Non-invasive Assessments of Adipose Tissue Metabolism In Vitro

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• 作者：Rosalyn D. Abbott ; Francis E. Borowsky ; Kyle P. Quinn…
• 关键词：Tissue engineering ; Non ; destructive characterization ; Optical imaging
• 刊名：Annals of Biomedical Engineering
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：44
• 期：3
• 页码：725-732
• 全文大小：1,031 KB
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• 作者单位：Rosalyn D. Abbott (1)
  Francis E. Borowsky (1)
  Kyle P. Quinn (1)
  David L. Bernstein (1)
  Irene Georgakoudi (1)
  David L. Kaplan (1)
  
  1. Biomedical Engineering, Tufts University, 4 Colby St., Medford, MA, 02155, USA
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Biomedicine
  Biomedical Engineering
  Biophysics and Biomedical Physics
  Mechanics
  Biochemistry
  
• 出版者：Springer Netherlands
• ISSN：1573-9686

文摘

Adipose tissue engineering is a diverse area of research where the developed tissues can be used to study normal adipose tissue functions, create disease models in vitro, and replace soft tissue defects in vivo. Increasing attention has been focused on the highly specialized metabolic pathways that regulate energy storage and release in adipose tissues which affect local and systemic outcomes. Non-invasive, dynamic measurement systems are useful to track these metabolic pathways in the same tissue model over time to evaluate long term cell growth, differentiation, and development within tissue engineering constructs. This approach reduces costs and time in comparison to more traditional destructive methods such as biochemical and immunochemistry assays and proteomics assessments. Towards this goal, this review will focus on important metabolic functions of adipose tissues and strategies to evaluate them with non-invasive in vitro methods. Current non-invasive methods, such as measuring key metabolic markers and endogenous contrast imaging will be explored.