Region-specific role of growth differentiation factor-5 in the establishment of sympathetic innervation
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- 作者：Gerard W. O'Keeffe ; Humberto Gutierrez ; Laura Howard…
- 关键词：Sympathetic neuron ; Axon growth ; Innervation ; GDF5
- 刊名：Neural Development
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：11
- 期：1
- 全文大小：2,009 KB
- 刊物主题：Neurosciences; Developmental Biology;
- 出版者：BioMed Central
- ISSN：1749-8104
文摘
Background Nerve growth factor (NGF) is the prototypical target-derived neurotrophic factor required for sympathetic neuron survival and for the growth and ramification of sympathetic axons within most but not all sympathetic targets. This implies the operation of additional target-derived factors for regulating terminal sympathetic axon growth and branching.