A porcine reproductive and respiratory syndrome virus (PRRSV) vaccine candidate based on the fusion protein of PRRSV glycoprotein 5 and the Toll-like Receptor-5 agonist Salmonella Typhimurium FljB
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- 作者：Dan Xiong ; Li Song ; Xianyue Zhai ; Shizhong Geng ; Zhiming Pan…
- 关键词：PRRSV ; Glycoprotein 5 ; Flagellin ; Fusion protein ; Vaccine
- 刊名：BMC Veterinary Research
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：11
- 期：1
- 全文大小：2,968 KB
- 刊物主题：Veterinary Medicine; Zoology; Transgenics;
- 出版者：BioMed Central
- ISSN：1746-6148
文摘
Background Porcine reproductive and respiratory syndrome (PRRS) is characterized by severe reproductive failure and severe pneumonia in neonatal pigs and is caused by PRRS virus (PRRSV). Glycoprotein 5 (GP5) from PRRSV is a key inducer of neutralizing antibodies. Flagellin, a toll-like receptor 5 (TLR-5) agonist, is an effective inducer of innate immune responses. This study presents a novel PRRSV vaccine candidate based on the adjuvant effect of Salmonella Typhimurium FljB fused with PRRSV GP5.