Characterization of the interaction between a platinum(II) complex and human serum albumin: spectroscopic analysis and molecular docking
详细信息 查看全文
- 作者：Somaye Shahraki ; Fereshteh Shiri…
- 关键词：Human serum albumin ; Pt(II) complex ; Multispectroscopic methods ; Molecular docking
- 刊名：Journal of the Iranian Chemical Society
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：13
- 期：4
- 页码：723-731
- 全文大小：1,331 KB
- 参考文献：1.X.M. He, D.C. Carter, Atomic structure and chemistry of human serum albumin, (1992)
2.N. Shahabadi, M. Maghsudi, J. Mol. Struct. 929, 193–199 (2009)CrossRef
3.D.C. Carter, J.X. Ho, Structure of serum albumin, (1994)
4.L. Kelland, Nat. Rev. Cancer 7, 573–584 (2007)CrossRef
5.S.R. McWhinney, R.M. Goldberg, H.L. McLeod, Mol. Cancer Ther. 8, 10–16 (2009)CrossRef
6.A.A. Argyriou, P. Polychronopoulos, G. Iconomou, E. Chroni, H.P. Kalofonos, Cancer Treat. Rev. 34, 368–377 (2008)CrossRef
7.X. Wang, Curr. Med. Chem. Anticancer Agents 10, 396–411 (2010)CrossRef
8.F. Gümüş, Ö. Algül, J. Inorg. Biochem. 68, 71–74 (1997)CrossRef
9.R. Olivova, J. Stepankova, T. Muchova, V. Novohradsky, O. Novakova, O. Vrana, J. Kasparkova, V. Brabec, Inorg. Chim. Acta 393, 204–211 (2012)CrossRef
10.C. Marzano, A. Trevisan, L. Giovagnini, D. Fregona, Toxicol. In Vitro 16, 413–419 (2002)CrossRef
11.D. Fregona, L. Giovagnini, L. Ronconi, C. Marzano, A. Trevisan, S. Sitran, B. Biondi, F. Bordin, J. Inorg. Biochem. 93, 181–189 (2003)CrossRef
12.R.T. Dorr, A review of the modulation of cisplatin toxicities by chemoprotectants, in Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy 2, (Springer, 1996), pp. 131–154
13.H. Mansouri-Torshizi, S. Shahraki, Z.S. Nezami, A. Ghahghaei, S. Najmedini, A. Divsalar, H. Ghaemi, A.-A. Saboury, Complex Met. 1, 23–31 (2014)CrossRef
14.C.N. Pace, F. Vajdos, L. Fee, G. Grimsley, T. Gray, Protein Sci. 4, 2411–2423 (1995)CrossRef
15.F.A. Momany, R. Rone, Validation of the general purpose QUANTA® 3.2/CHARMm® force field. J. Comput. Chem. 13, 888–900 (1992)CrossRef
16.D. Studio, version 2.5, Accelrys Inc.: San Diego, CA, USA, (2009)
17.O. Trott, A.J. Olson, J. Comput. Chem. 31, 455–461 (2010)
18.D. Seeliger, B.L. de Groot, J. Comput. Aided Mol. Des. 24, 417–422 (2010)CrossRef
19.M.L. Verdonk, V. Berdini, M.J. Hartshorn, W.T. Mooij, C.W. Murray, R.D. Taylor, P. Watson, J. Chem. Inform. Comput. Sci. 44, 793–806 (2004)CrossRef
20.G. Jones, P. Willett, R.C. Glen, A.R. Leach, R. Taylor, J. Mol. Biol. 267, 727–748 (1997)CrossRef
21.S.Z. Bathaie, A. Bolhasani, R. Hoshyar, B. Ranjbar, F. Sabouni, A.A. Moosavi-Movahedi, DNA Cell Biol. 26, 533–540 (2007)CrossRef
22.Y. Yue, X. Chen, J. Qin, X. Yao, Colloid Surf B. 69, 51–57 (2009)CrossRef
23.O.K. Abou-Zied, O.I. Al-Shihi, J. Am. Chem. Soc. 130, 10793–10801 (2008)CrossRef
24.E. Froehlich, J. Mandeville, C. Jennings, R. Sedaghat-Herati, H. Tajmir-Riahi, J. Am. Chem. Soc. B 113, 6986–6993 (2009)
25.J.R. Lackowicz, Principles of fluorescence spectroscopy, vol. 5 (Plenum Press, New York, 1983), pp. 111–150CrossRef
26.O. Stern, M. Volmer, Phys. Z. 20, 183–188 (1919)
27.S. Bi, H. Zhang, C. Qiao, Y. Sun, C. Liu, Spectrochim. Acta A. 69, 123–129 (2008)CrossRef
28.W.R. Ware, J. Phys. Chem. 66, 455–458 (1962)CrossRef
29.K.A. Connors, Binding constants: the measurement of molecular complex stability (Wiley, New York, 1987)
30.P. Qu, H. Lu, X. Ding, Y. Tao, Z. Lu, J. Mol. Struct. 920, 172–177 (2009)CrossRef
31.L. Stryer, Annu. Rev. Biochem. 47, 819–846 (1978)CrossRef
32.D.E. Epps, T.J. Raub, V. Caiolfa, A. Chiari, M. Zamai, J. Pharm. Pharmacol. 51, 41–48 (1999)CrossRef
33.W. He, Y. Li, C. Xue, Z. Hu, X. Chen, F. Sheng, Bioorg. Med. Chem. 13, 1837–1845 (2005)CrossRef
34.L. Trynda-Lemiesz, A. Karaczyn, B.K. Keppler, H. Kozlowski, J. Inorg. Biochem. 78, 341–346 (2000)CrossRef
35.W.K. Surewicz, H.H. Mantsch, D. Chapman, Biochemistry 32, 389–394 (1993)CrossRef - 作者单位：Somaye Shahraki (1)
Fereshteh Shiri (1)
Hassan Mansouri-Torshizi (2)
Jafar Shahraki (3)
1. Department of Chemistry, University of Zabol, Zabol, Iran
2. Department of Chemistry, University of Sistan and Baluchestan, Zahedan, Iran
3. Department of Pharmacology and Toxicology, Faculty of Pharmacy, Zabol University of Medical Sciences, Zabol, Iran - 刊物主题：Analytical Chemistry; Inorganic Chemistry; Physical Chemistry; Biochemistry, general; Organic Chemistry;
- 出版者：Springer Berlin Heidelberg
- ISSN：1735-2428
文摘
In this study, the interaction between (2,2ʹ-bipyridine)(pyrrolidinedithiocarbamato) platinum(II) nitrate, [Pt(bpy)(pyr-dtc]NO3, and human serum albumin (HSA) was investigated by various spectroscopic methods (UV–vis, fluorescence, CD and FT-IR) and molecular docking technique at three temperatures. UV–vis absorption spectroscopy showed that Pt(II) complex can denature the protein at moderate concentrations. The results of emission quenching at two temperatures has revealed that the quenching mechanism of Pt(II) complex with HSA was static quenching mechanism. Binding constants (K), binding site number (n) and corresponding thermodynamic parameters ∆G˚, ∆H˚ and ∆S˚ were calculated and revealed that hydrophobic forces played a major role when Pt(II) complex interacted with HSA. The binding distance (r) between above complex and HSA based on Försterʼs theory of non-radiation energy transfer was calculated as 3.22 nm. Alterations of HSA secondary structure induced by complex were confirmed by FT-IR and CD measurements. Also, a molecular docking study was performed for identification of key structural features of binding of the Pt complex into the receptor and predicting bioactive conformers. Our results may provide valuable information to understand the mechanistic pathway of drug delivery and to pharmacological behavior of drug. Keywords Human serum albumin Pt(II) complex Multispectroscopic methods Molecular docking