Synthesis, physico-chemical characterization and bacteriostatic study of Pt complexes with substituted amine ligands

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• 作者：B. Barta Holló ; I. M. Szilágyi…
• 关键词：Pt(II) complexes ; Amine ligand ; Thermal properties ; Spectroscopic data ; Antimicrobial activity
• 刊名：Journal of Thermal Analysis and Calorimetry
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：127
• 期：2
• 页码：1733-1741
• 全文大小：
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Physical Chemistry; Analytical Chemistry; Polymer Sciences; Inorganic Chemistry; Measurement Science and Instrumentation;
• 出版者：Springer Netherlands
• ISSN：1588-2926
• 卷排序：127

文摘

Three complexes of general formula PtCl₂R₂ were synthesized, where R is the amine ligand with aromatic substituents. Coordination compounds [Pt(an)₂Cl₂] (1), [Pt(pa)₂Cl₂] (2) and [Pt(aph)₂Cl₂] (3), where an = 2-aminonaphthalene, pa = 2-aminopyrimidine, aph = 4-anilinophenol, were characterized by on-line coupled TG/DTA-MS, powder XRD and spectroscopic techniques (FTIR, ESI–MS and NMR), and tested against selected Gram(+) and Gram(–) bacteria. The thermal data show that all three compounds contain lattice or absorbed water, and the stability of the anhydrous compounds in nitrogen decreases in the order 2 > 1 > 3. Above 200 °C, the complexes loose characteristic fragments of their ligands. The spectroscopic data are in accordance with the thermal properties of the samples and prove their composition. The compounds are more effective inhibitors of Gram(+) than Gram(−) bacteria.