Synthesis and antitumor activity of pyridoxine monoalkenyl derivatives

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• 作者：M. V. Pugachev ; R. S. Pavelyev ; T. N. T. Nguyen…
• 关键词：Key wordspyridoxine ; quaternary phosphonium salts ; Wittig reaction ; alkenyl derivatives ; antitumor activity ; cytotoxicity
• 刊名：Russian Chemical Bulletin
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：65
• 期：2
• 页码：532-536
• 全文大小：227 KB
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Chemistry
  Organic Chemistry
  Inorganic Chemistry
  Russian Library of Science
  
• 出版者：Springer New York
• ISSN：1573-9171
• 卷排序：65

文摘

A convenient method for the synthesis of pyridoxine alkenyl derivatives by the Wittig reaction of [(2,8-dimethyl-4H-[1,3]dioxino[4,5-c]pyridin-5-yl)methyl]triphenylphosphonium chloride with aldehydes was suggested. Some of the compounds obtained exhibit antitumor activity in vitro.