SIMIFF study: Italian fungal registry of mold infections in hematological and non-hematological patients
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- 作者：M. T. Montagna (1)
G. Lovero (1)
C. Coretti (1)
D. Martinelli (2)
M. Delia (3)
O. De Giglio (1)
M. Caira (4)
F. Puntillo (5)
D. D’Antonio (6)
M. Venditti (7)
V. Sambri (8)
F. Di Bernardo (9)
A. Barbui (10)
G. Lo Cascio (11)
E. Concia (12)
M. Mikulska (13)
C. Viscoli (13)
N. Maximova (14)
A. Candoni (15)
S. Oliveri (16)
G. Lombardi (17)
L. Pitzurra (18)
M. Sanguinetti (19)
R. Masciari (20)
T. Santantonio (21)
S. Andreoni (22)
F. Barchiesi (23)
P. Pecile (24)
C. Farina (25)
P. Viale (26)
G. Specchia (3)
G. Caggiano (1)
L. Pagano (4) - 关键词：Filamentous fungal infections ; Italian survey ; Hematological patients ; Non ; hematological patients
- 刊名：Infection
- 出版年：2014
- 出版时间：February 2014
- 年：2014
- 卷：42
- 期：1
- 页码：141-151
- 全文大小：303 KB
- 作者单位：M. T. Montagna (1)
G. Lovero (1)
C. Coretti (1)
D. Martinelli (2)
M. Delia (3)
O. De Giglio (1)
M. Caira (4)
F. Puntillo (5)
D. D’Antonio (6)
M. Venditti (7)
V. Sambri (8)
F. Di Bernardo (9)
A. Barbui (10)
G. Lo Cascio (11)
E. Concia (12)
M. Mikulska (13)
C. Viscoli (13)
N. Maximova (14)
A. Candoni (15)
S. Oliveri (16)
G. Lombardi (17)
L. Pitzurra (18)
M. Sanguinetti (19)
R. Masciari (20)
T. Santantonio (21)
S. Andreoni (22)
F. Barchiesi (23)
P. Pecile (24)
C. Farina (25)
P. Viale (26)
G. Specchia (3)
G. Caggiano (1)
L. Pagano (4)
1. Hygiene Section, Department of Biomedical Science and Human Oncology, University of Bari, Piazza Giulio Cesare 11, 70124, Bari, Italy
2. Hygiene Section, Department of Medical and Surgical Sciences, University of Foggia, Via Gramsci 89-91, 71100, Foggia, Italy
3. Hematology Section, Department of Emergency and Organ Transplantation, University of Bari, Piazza Giulio Cesare 11, 70124, Bari, Italy
4. Hematology Institute, University Cattolica S. Cuore, Largo Francesco Vito 1, 00168, Rome, Italy
5. Anesthesia and Intensive Care Unit, Department of Emergency and Organ Transplantation, University of Bari, Piazza Giulio Cesare 11, 70124, Bari, Italy
6. Clinical Microbiology and Virology, Hospital Spirito Santo, Via Fonte Romana 8, 65100, Pescara, Italy
7. Department of Public Health and Infectious Diseases, University La Sapienza, Piazzale Aldo Moro 5, 00185, Rome, Italy
8. Clinical Microbiology Unit, University Hospital St. Orsola, Via Pietro Albertoni 15, 40138, Bologna, Italy
9. Laboratory of Clinical Microbiology, ARNAS General Hospital Civico, Piazzale Liotti 4, 90127, Palermo, Italy
10. SC Microbiology and Virology, Hospital Città della Salute e della Scienza, Corso Bramante 88, 10126, Turin, Italy
11. Microbiology and Virology Unit, Department of Pathology and Diagnostic, University of Verona, Piazzale A. Scuro 10, 37134, Verona, Italy
12. Department of Pathology, University of Verona, Piazzale A. Scuro 10, 37134, Verona, Italy
13. Infectious Diseases Division, Department of Health Sciences, University Hospital IRCCS San Martino, Largo Rosanna Benzi 10, 16132, Genoa, Italy
14. Oncohematology, Institute for Maternal and Child Health, IRCCS Burlo Garofolo, Via dell’Istria 65/1, 34137, Trieste, Italy
15. Division of Hematology and Bone Marrow Transplantation, University of Udine, Via Palladio 8, 33100, Udine, Italy
16. Department of Biomedical Science, University of Catania, Piazza dell’Università 2, 95124, Catania, Italy
17. Microbiology and Virology Laboratory, Hospital Niguarda-Ca-Granda, Piazza Ospedale Maggiore 3, 20162, Milan, Italy
18. Department of Experimental Medicine, University of Perugia, Piazza Università 1, 06123, Perugia, Italy
19. Department of Experimental Medicine, Institute of Microbiology, University Cattolica S. Cuore, Largo Francesco Vito 1, 00168, Rome, Italy
20. Microbiology and Virology Laboratory, A.O. Pugliese Ciaccio, Via Vinicio Cortese 25, 88100, Catanzaro, Italy
21. Clinic of Infectious Diseases, University of Foggia, Via Gramsci 89-91, 71100, Foggia, Italy
22. Microbiology and Virology Laboratory, AOU Maggiore della Carità, Corso Mazzini 18, 28100, Novara, Italy
23. Clinic of Infectious Diseases, Department of Biomedical Sciences and Public Health, University of Marche, Piazza Roma 22, 60121, Ancona, Italy
24. Microbiology Laboratory, Hospital Careggi, Viale Morgagni, 50134, Florence, Italy
25. Microbiology Institute, Hospital San Carlo Borromeo, Via Pio II 3, 20147, Milan, Italy
26. Infectious Diseases Unit, Department of Medical and Surgical Sciences, University of Bologna, Via Zamboni 33, 40126, Bologna, Italy - ISSN：1439-0973
文摘
Purpose We compared the risk factors, the diagnostic tools and the outcome of filamentous fungal infections (FFIs) in hematological patients (HAEs) and non-hematological patients (non-HAEs). Methods Prospective surveillance (2009-011) of proven and probable FFIs was implemented in 23 Italian hospitals. Results Out of 232 FFIs, 113 occurred in HAEs and 119 in non-HAEs. The most frequent infection was invasive aspergillosis (76.1?% for HAEs, 56.3?% for non-HAEs), and the localization was principally pulmonary (83.2?% for HAEs, 74.8?% for non-HAEs). Neutropenia was a risk factor for 89.4?% HAEs; the main underlying condition was corticosteroid treatment (52.9?%) for non-HAEs. The distribution of proven and probable FFIs was different in the two groups: proven FFIs occurred more frequently in non-HAEs, whereas probable FFIs were correlated with the HAEs. The sensitivity of the galactomannan assay was higher for HAEs than for non-HAEs (95.3 vs. 48.1?%). The overall mortality rate was 44.2?% among the HAEs and 35.3?% among the non-HAEs. The etiology influenced the patient outcomes: mucormycosis was associated with a high mortality rate (57.1?% for HAEs, 77.8?% for non-HAEs). Conclusions The epidemiological and clinical data for FFIs were not identical in the HAEs and non-HAEs. The differences should be considered to improve the management of FFIs according to the patients-setting.