New trends in biotechnological production of rosmarinic acid

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• 作者：Abbas Khojasteh (1)
  Mohammad Hossein Mirjalili (2)
  Diego Hidalgo (4)
  Purificación Corchete (3)
  Javier Palazon (4)
  
• 关键词：Biosensors ; Hairy root culture ; Metabolic engineering ; Plant cell culture ; Rosmarinic acid ; Single ; use technology
• 刊名：Biotechnology Letters
• 出版年：2014
• 出版时间：December 2014
• 年：2014
• 卷：36
• 期：12
• 页码：2393-2406
• 全文大小：786 KB
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  2. Bauer N, Kiseljak D, Jelaska S (2009) The effect of yeast extract and methyl jasmonate on rosmarinic acid accumulation in / Coleus blumei hairy roots. Biol Plant 53:650-56 CrossRef
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  11. Eibl R, Kaiser S, Lombriser R, Eibl D (2010) Disposable bioreactors: the current state-of-the-art and recommended applications in biotechnology. Appl Microbiol Biotechnol 86:41-9 CrossRef
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  13. Eremia SAV, Radu G-L, Litescu S-C (2013) Monitoring of rosmarinic acid accumulation in sage cell cultures using laccase biosensor. Phytochem Anal 24:53-8 CrossRef
  14. Fallarini S, Miglio G, Paoletti T, Minassi A, Amoruso A, Bardelli C, Brunelleschi S, Lombardi G (2009) Clovamide and rosmarinic acid induce neuroprotective effects in in vitro models of neuronal death. Br J Pharmacol 157:1072-084 CrossRef
  15. Fattahi M, Nazerib V, Torras-Claveria L, Sefidkond F, Cusido RM, Zamani Z, Palazon J (2013) A new biotechnological source of rosmarinic acid and surface flavonoids: hairy root cultures of / Dracocephalum kotschyi Boiss. Ind Crops Prod 50:256-63 CrossRef
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• 作者单位：Abbas Khojasteh (1)
  Mohammad Hossein Mirjalili (2)
  Diego Hidalgo (4)
  Purificación Corchete (3)
  Javier Palazon (4)
  
  1. Institute of Biotechnology, Biochemical Engineering and Cell Cultivation Techniques, Zurich University of Applied Sciences, Campus Grüental, W?denswil, Switzerland
  2. Department of Agriculture, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, G. C., Tehran, Iran
  4. Laboratori de Fisiologia Vegetal, Facultat de Farmacia, Universitat de Barcelona, Av. Joan XXIII sn, 08028, Barcelona, Spain
  3. Department of Plant Physiology, Campus Miguel de Unamuno, University of Salamanca, 37007, Salamanca, Spain
  
• ISSN：1573-6776

文摘

Rosmarinic acid (RA), an ester of caffeic acid and 3,4-dihydroxyphenyl lactic acid, is widely distributed in the plant kingdom. Interest in it is growing due to its promising biological activities, including cognitive-enhancing effects and slowing the development of Alzheimer’s disease, cancer chemoprotection or anti-inflammatory activity, among others. In order to meet the increasing demand for this compound, several biotechnological approaches to its production based on plant cell and hairy root cultures have been developed. Empirical strategies are currently being combined with metabolic engineering tools to increase RA production in plant cell platforms in a more rational way. Discussed here are the latest advances in the field, together with recent trends in plant biotechnology, such as the application of single use technology and the use of biosensors in downstream processes.