An efficient catalyst- and solvent-free method for the synthesis of medicinally important dihydropyrano[2,3-c]pyrazole derivatives using ball milling technique

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• 作者：Mohammad G. Dekamin ; Mohammad Alikhani…
• 关键词：Catalyst ; free conditions ; Solvent ; free conditions ; Ball milling technique ; Green chemistry ; Multicomponent reactions (MCRs) ; Dihydropyrano[2 ; 3 ; c]pyrazole scaffold
• 刊名：Journal of the Iranian Chemical Society
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：13
• 期：3
• 页码：591-596
• 全文大小：530 KB
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• 作者单位：Mohammad G. Dekamin (1)
  Mohammad Alikhani (1)
  Atefeh Emami (1)
  Hossein Ghafuri (1)
  Shahrzad Javanshir (1)
  
  1. Pharmaceutical and Heterocyclic Compounds Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran, 16846-13114, Iran
  
• 刊物主题：Analytical Chemistry; Inorganic Chemistry; Physical Chemistry; Biochemistry, general; Organic Chemistry;
• 出版者：Springer Berlin Heidelberg
• ISSN：1735-2428

文摘

Dihydropyrano[2,3-c]pyrazole annulated heterocyclic compounds with diverse substituents on the 4H-pyran ring were efficiently prepared via a one-pot and four-component reaction of ethyl acetoacetate, hydrazine hydrate, aromatic aldehyde, and malononitrile. The procedure proceeds without utilization of any catalyst or solvent using ball milling technique at ambient temperature to afford desired medicinally important dihydropyrano[2,3-c]pyrazole derivatives. This protocol offers several advantages such as avoiding the use of any toxic and hazardous catalyst or solvent, mild reaction conditions, high to quantitative yields of products, low cost, and straightforward work-up.