Synthesis and some properties of N-unsubstituted pyrrolo[2,1-c]-1,3-diazacycloalkano[1,2-a]pyrazinones

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• 作者：G. V. Mokrov (1) g.mokrov@gmail.com
  A. M. Likhosherstov (1)
  V. P. Lezina (1)
  T. A. Gudasheva (1)
  I. S. Bushmarinov (2)
  M. Yu. Antipin (2)
• 关键词：Key words aliphatic diamines – ; formyl ; containing acid esters – ; amino lactams – ; reduction – ; quantum chemical calculations – ; keto ; enol tautomerism – ; ring ; chain tautomerism – ; pyrrole ; containing heterocyclic systems – ; X ; ray diffraction analysis – ; NMR spectroscopy
• 刊名：Russian Chemical Bulletin
• 出版年：2011
• 出版时间：August 2011
• 年：2011
• 卷：60
• 期：8
• 页码：1694-1702
• 全文大小：392.6 KB
• 参考文献：1. G. V. Mokrov, A. M. Likhosherstov, V. P. Lezina, T. A. Guda- sheva, I. S. Bushmarinov, M. Yu. Antipin, Izv. Akad. Nauk, Ser. Khim., 2010, 1228 [Russ. Chem. Bull., Int. Ed., 2010, 59, 1254].
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• 作者单位：1. V. V. Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences, 8 ul. Baltiiskaya, 125315 Moscow, Russian Federation2. A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, 28 ul. Vavilova, 119991 Moscow, Russian Federation
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Chemistry
  Organic Chemistry
  Inorganic Chemistry
  Russian Library of Science
  
• 出版者：Springer New York
• ISSN：1573-9171

文摘

Reactions of methyl 2-(2-formyl-1H-pyrrol-1-yl)alkanoates with unsubstituted aliphatic 1,2-, 1,3-, and 1,4-diamines gave N-unsubstituted pyrrolo[2,1-c]-1,3-diazacycloalkano[1,2-a]-pyrazinones. Some of them show ring-chain tautomerism. Transformations of these compounds led to a number of novel heterocyclic systems: 2,10-dihydro-3H,5H-imidazo[1,2-a]-pyrrolo[1,2-d]pyrazines, 2,3,4,11-tetrahydro-6H-pyrrolo[1′,2′:4,5]pyrazino[1,2-a]pyrimidines, 1,2,3,5,6,10b-hexahydroimidazo[1,2-a]pyrrolo[2,1-c]pyrazines, 1,3,4,6,7,11b-hexahydro-2H-pyrrolo[2′,1′:3,4]pyrazino[1,2-a]pyrimidines, and 2,3,4,5,6,7-hexahydro-1H-pyrrolo[2,1-c]-[1,4,7]triazacycloundecin-8(9H)-one.