Synthesis, spectroscopic, magnetic and biological activity studies of copper(II) complexes of an antipyrine Schiff base

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• 作者：Kamal Z. Ismail
• 刊名：Transition Metal Chemistry
• 出版年：2000
• 出版时间：2000
• 年：2000
• 卷：25
• 期：5
• 页码：522-528
• 全文大小：119 KB

文摘

The Schiff base, 4-(2-pyrrolylmethylideneamino)antipyrine (HPAP), (1), and its copper(II) complexes were synthesized and characterized by elemental analysis and by physical and spectral methods such as i.r., u.v.–vis., 1H-n.m.r., 13C-n.m.r. and e.s.r. as well as by molar conductance and magnetic moment determinations. Both the bis-ligand, [(HPAP)₂Cu]X₂(4, 5), [(PAP)₂Cu] (6), and the dimer, [(PAP)Cu]₂X₂(2, 3), complexes were isolated. In these complexes, the Schiff base acts as a bidentate or tridentate neutral or monobasic ligand. Interaction of the isolated [(PAP)Cu]₂Cl₂(2), with strong coordinating organic bases was studied and the resultant adducts, [(PAP)CuLs]Cl; Ls = pyridine (7), -picoline (8), -picoline (9), -picoline (10) or n-propylamine (11), were isolated and characterized. Biological activity screening was studied and an activity correlation coefficients matrix was constructed for HPAP and the copper(II) complexes against gram-positive, gram-negative and fungi species. The copper content, structure of the complex as well as the degree of exposure of the metal center control the biological activity of the isolated complexes.