Highlights on mechanisms of drugs targeting MDSCs: providing a novel perspective on cancer treatment

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• 作者：Wei Pan ; Qian Sun ; Yang Wang ; Jian Wang ; Shui Cao ; Xiubao Ren
• 关键词：MDSCs ; Mechanisms ; Tumor microenvironment ; Subpopulation ; Functional regulation ; Therapeutic implication
• 刊名：Tumor Biology
• 出版年：2015
• 出版时间：May 2015
• 年：2015
• 卷：36
• 期：5
• 页码：3159-3169
• 全文大小：416 KB
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• 作者单位：Wei Pan (1) (2) (3) (4)
  Qian Sun (1) (3) (4)
  Yang Wang (1) (2) (3) (4)
  Jian Wang (1) (3) (4)
  Shui Cao (1) (2) (3) (4)
  Xiubao Ren (1) (2) (3) (4)
  
  1. Department of immunology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, 300060, China
  2. Department of Biotherapy, Tianjin Medical University Cancer Institute and Hospital, Tianjin, 300060, China
  3. Key Laboratory of Cancer Immunology and Biotherapy, Tianjin, 300060, China
  4. National Clinical Research Center of Cancer, Tianjin, 300060, China
  
• 刊物主题：Cancer Research;
• 出版者：Springer Netherlands
• ISSN：1423-0380

文摘

The hallmark of tumor microenvironment is that it makes up of numerous immunomodulatory cells and factors which exert essential roles in immunoprotection and immunosuppression in addition to tumor cells. Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature myeloid cells reported to promote immunosuppression and angiogenesis and facilitate tumor metastasis and invasion. The wide scope of MDSCs functional activities make these cells promising targets for effective cancer treatments. In this review, we briefly discuss the origin, subpopulation, and functions of MDSCs, as well as the potential to target these cells for therapeutic benefit. We focus on the underlying molecular mechanisms of these drugs targeting MDSCs, mainly from the standpoint of molecules related to drug targets.