Genetic Evolution during the development of an attenuated EIAV vaccine

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• 作者：Xue-Feng Wang ; Yue-Zhi Lin ; Qiang Li ; Qiang Liu ; Wei-Wei Zhao ; Cheng Du…
• 关键词：EIAV ; Genetic Evolution ; Lentiviral vaccine
• 刊名：Retrovirology
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：13
• 期：1
• 全文大小：2,802 KB
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• 作者单位：Xue-Feng Wang (1) (2)
  Yue-Zhi Lin (1)
  Qiang Li (1) (3)
  Qiang Liu (1)
  Wei-Wei Zhao (1)
  Cheng Du (1)
  Jie Chen (1)
  Xiaojun Wang (1)
  Jian-Hua Zhou (1) (4)
  
  1. State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, 150001, China
  2. Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northeast Agricultural University, Harbin, China
  3. Harbin Weike Biotechnology Development Company, Harbin, China
  4. Harbin Pharmaceutical Group Biovaccine Co., Harbin, 150069, China
  
• 刊物主题：Virology; Infectious Diseases; Cancer Research;
• 出版者：BioMed Central
• ISSN：1742-4690

文摘

Background The equine infectious anemia virus (EIAV) vaccine is the only attenuated lentiviral vaccine applied on a large scale that has been shown to be effective in controlling the prevalence of EIA in China. This vaccine was developed by successive passaging of a field-isolated virulent strain in different hosts and cultivated cells. To explore the molecular basis for the phenotype alteration of this vaccine strain, we systematically analyzed its genomic evolution during vaccine development.