Selective Modulation of Histaminergic Inputs on Projection Neurons of Cerebellum Rapidly Promotes Motor Coordination via HCN Channels

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• 作者：Jun Zhang ; Qian-Xing Zhuang ; Bin Li ; Guan-Yi Wu ; Wing-Ho Yung…
• 关键词：Histamine ; Histamine H2 receptor ; HCN channel ; Cerebellar nuclei ; Projection neurons ; Motor control
• 刊名：Molecular Neurobiology
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：53
• 期：2
• 页码：1386-1401
• 全文大小：4,856 KB
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• 作者单位：Jun Zhang (1) (3)
  Qian-Xing Zhuang (1)
  Bin Li (1)
  Guan-Yi Wu (1)
  Wing-Ho Yung (2)
  Jing-Ning Zhu (1)
  Jian-Jun Wang (1)
  
  1. State Key Laboratory of Pharmaceutical Biotechnology and Department of Biological Science and Technology, School of Life Sciences, Nanjing University, Mailbox 426, 22 Hankou Road, Nanjing, 210093, China
  3. Department of Physiology, Third Military Medical University, Chongqing, 400038, China
  2. School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China
  
• 刊物主题：Neurosciences; Neurobiology; Cell Biology; Neurology;
• 出版者：Springer US
• ISSN：1559-1182

文摘

Insights into function of central histaminergic system, a general modulator originating from the hypothalamus for whole brain activity, in motor control are critical for understanding the mechanism underlying somatic-nonsomatic integration. Here, we show a novel selective role of histamine in the cerebellar nuclei, the final integrative center and output of the cerebellum. Histamine depolarizes projection neurons but not interneurons in the cerebellar nuclei via the hyperpolarization-activated cyclic nucleotide-gated (HCN) channels coupled to histamine H2 receptors, which are exclusively expressed on glutamatergic and glycinergic projection neurons. Furthermore, blockage of HCN channels to block endogenous histaminergic afferent inputs in the cerebellar nuclei significantly attenuates motor balance and coordination. Therefore, through directly and quickly modulation on projection neurons but not interneurons in the cerebellar nuclei, central histaminergic system may act as a critical biasing force to not only promptly regulate ongoing movement but also realize a rapid integration of somatic and nonsomatic response. Keywords Histamine Histamine H2 receptor HCN channel Cerebellar nuclei Projection neurons Motor control