Elevated apolipoprotein A-I levels are associated with favorable prognosis in metastatic nasopharyngeal carcinoma

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• 作者：Rou Jiang (1) (2) (4)
  Zhong-Han Yang (3)
  Dong-Hua Luo (1) (2)
  Ling Guo (1) (2)
  Rui Sun (1) (2)
  Qiu-Yan Chen (1) (2)
  Pei-Yu Huang (1) (2)
  Fang Qiu (1) (2)
  Xiong Zou (1) (2)
  Ka-Jia Cao (1) (2)
  Hai-Qiang Mai (1) (2)
  Xiang Guo (1) (2)
  Chao-Nan Qian (1) (2)
  Ming-Huang Hong (1) (2)
  Ming-Yuan Chen (1) (2)
  
• 关键词：Metastatic nasopharyngeal carcinoma ; Serum lipid and lipoprotein ; Apolipoprotein A ; I ; Overall survival ; Prognosis
• 刊名：Medical Oncology
• 出版年：2014
• 出版时间：August 2014
• 年：2014
• 卷：31
• 期：8
• 全文大小：643 KB
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• 作者单位：Rou Jiang (1) (2) (4)
  Zhong-Han Yang (3)
  Dong-Hua Luo (1) (2)
  Ling Guo (1) (2)
  Rui Sun (1) (2)
  Qiu-Yan Chen (1) (2)
  Pei-Yu Huang (1) (2)
  Fang Qiu (1) (2)
  Xiong Zou (1) (2)
  Ka-Jia Cao (1) (2)
  Hai-Qiang Mai (1) (2)
  Xiang Guo (1) (2)
  Chao-Nan Qian (1) (2)
  Ming-Huang Hong (1) (2)
  Ming-Yuan Chen (1) (2)
  
  1. Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, 651 Dongfeng East Road, Guangzhou, 510060, People’s Republic of China
  2. State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, 651 Dongfeng East Road, Guangzhou, 510060, People’s Republic of China
  4. Department of Cancer Prevention, Sun Yat-sen University Cancer Center, 651 Dongfeng East Road, Guangzhou, 510060, People’s Republic of China
  3. Department of Biochemistry, Zhong Shan School of Medicine, Sun Yat-sen University, 74 Zhongshan No. 2 Road, Guangzhou, 510080, People’s Republic of China
  
• ISSN：1559-131X

文摘

The survival outcomes of patients with metastatic nasopharyngeal carcinoma (NPC) differ significantly between individuals. Serum lipids and lipoproteins have been reported to be associated with prognosis in some cancers, but it has not been studied in metastatic NPC. The aim of this study was to evaluate whether serum lipid and lipoproteins could predict the prognosis of metastatic NPC patients. Eight hundred and seven patients with metastatic NPC were analyzed retrospectively, and the values of serum lipids and lipoproteins at baseline were retrieved. Receiver operating characteristic curve analysis and univariate and multivariate Cox proportional hazards analyses were used to evaluate the associations of serum lipids and lipoproteins with overall survival (OS). Univariate analysis revealed that higher values of baseline cholesterol (?.655?mmol/L), baseline high-density lipoprotein cholesterol (?.965?mmol/L), and baseline apolipoprotein A-I (ApoA-I) (?.065?g/L) were significantly associated with superior OS (p?p?