Influences of different vasopressors on stroke volume variation and pulse pressure variation

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• 作者：Ran Kong ; Yi Liu ; Weidong Mi ; Qiang Fu
• 关键词：Phenylephrine ; Dopamine ; Ephedrine ; Pulse pressure variation ; Stroke volume variation
• 刊名：Journal of Clinical Monitoring and Computing
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：30
• 期：1
• 页码：81-86
• 全文大小：348 KB
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• 作者单位：Ran Kong (1)
  Yi Liu (1)
  Weidong Mi (1)
  Qiang Fu (1)
  
  1. Department of Anesthesiology, People’s Liberation Army General Hospital, 28 Fuxing Road, Haidian District, Beijing, 100853, China
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Anesthesiology
  Intensive and Critical Care Medicine
  Statistics for Life Sciences, Medicine and Health Sciences
  
• 出版者：Springer Netherlands
• ISSN：1573-2614

文摘

Pulse pressure variation (PPV) and stroke volume variation (SVV) during mechanical ventilation have been shown to be effective parameters to predict preload responsiveness. Although induced hypertension decreases PPV and SVV, the influences of different vasopressors on PPV and SVV are unknown. 94 patients undergoing elective otologic surgery were randomly divided into three groups: Group P (patients were given phenylephrine), Group D (patients were given dopamine), Group E (patients were given ephedrine). When surgery was ongoing and the circulation state was stable, patients were given the vasopressor to increase the systolic arterial pressure (SAP) to the pre-calculated levels: low level, 10 % < ΔSAP ≤ 20 %; medium level, 20 % < ΔSAP ≤ 30 %; high level, 30 % < ΔSAP ≤ 40 %. When invasive arterial pressure reached the target value, PPV, SVV and other parameters were recorded. Dopamine decreased the PPV and SVV more significantly than ephedrine, but less significantly than phenylephrine. The influences of phenylephrine, dopamine and ephedrine on SVV and PPV are different due to their different pharmacological mechanisms. Keywords Phenylephrine Dopamine Ephedrine Pulse pressure variation Stroke volume variation