Analysis and meta-analysis of five polymorphisms of the LINGO1 and LINGO2 genes in Parkinson's disease and multiple system atrophy in a Chinese population

详细信息    查看全文

• 作者：YongPing Chen ; Bei Cao ; Jing Yang ; QianQian Wei ; Ru Wei Ou ; Bi Zhao…
• 关键词：Parkinson’s disease ; Multiple system atrophy ; LINGO1 ; LINGO2 ; Polymorphisms
• 刊名：Journal of Neurology
• 出版年：2015
• 出版时间：November 2015
• 年：2015
• 卷：262
• 期：11
• 页码：2478-2483
• 全文大小：372 KB
• 参考文献：1.Agundez JA, Lorenzo-Betancor O, Pastor P, Garcia-Martin E, Luengo A, Alonso-Navarro H, Jimenez-Jimenez FJ (2012) LINGO1 rs9652490 and rs11856808 are not associated with the risk of Parkinson’s disease: results of a meta-analysis. Parkinsonism Relat Disord 18:657–659CrossRef PubMed
  2.Annesi F, De Marco EV, Rocca FE, Nicoletti A, Pugliese P, Nicoletti G, Arabia G, Tarantino P, De Mari M, Lamberti P, Gallerini S, Marconi R, Epifanio A, Morgante L, Cozzolino A, Barone P, Torchia G, Zappia M, Annesi G, Quattrone A (2011) Association study between the LINGO1 gene and Parkinson’s disease in the Italian population. Parkinsonism Relat Disord 17:638–641CrossRef PubMed
  3.Bialecka M, Kurzawski M, Tan EK, Drozdzik M (2010) Analysis of LINGO1 (rs9652490) polymorphism in sporadic Parkinson’s disease in a Polish population, and a meta-analysis. Neurosci Lett 472:53–55CrossRef PubMed
  4.Calne DB, Snow BJ, Lee C (1992) Criteria for diagnosing Parkinson’s disease. Ann Neurol 32(Suppl):S125–S127CrossRef PubMed
  5.Clarke GM, Anderson CA, Pettersson FH, Cardon LR, Morris AP, Zondervan KT (2011) Basic statistical analysis in genetic case–control studies. Nat Protoc 6:121–133PubMedCentral CrossRef PubMed
  6.Delay C, Tremblay C, Brochu E, Paris-Robidas S, Emond V, Rajput AH, Rajput A, Calon F (2014) Increased LINGO1 in the cerebellum of essential tremor patients. Mov Disord 29:1637–1647
  7.Gilman S, Wenning GK, Low PA, Brooks DJ, Mathias CJ, Trojanowski JQ, Wood NW, Colosimo C, Durr A, Fowler CJ, Kaufmann H, Klockgether T, Lees A, Poewe W, Quinn N, Revesz T, Robertson D, Sandroni P, Seppi K, Vidailhet M (2008) Second consensus statement on the diagnosis of multiple system atrophy. Neurology 71:670–676PubMedCentral CrossRef PubMed
  8.Guo XY, Chen YP, Song W, Zhao B, Cao B, Wei QQ, Ou RW, Yang Y, Yuan LX, Shang HF (2014) SNCA variants rs2736990 and rs356220 as risk factors for Parkinson’s disease but not for amyotrophic lateral sclerosis and multiple system atrophy in a Chinese population. Neurobiol Aging 35:2882.e2881–e2886
  9.Guo Y, Jankovic J, Song Z, Yang H, Zheng W, Le W, Tang X, Deng X, Yang Y, Deng S, Luo Z, Deng H (2011) LINGO1 rs9652490 variant in Parkinson disease patients. Neurosci Lett 487:174–176CrossRef PubMed
  10.Haubenberger D, Hotzy C, Pirker W, Katzenschlager R, Brucke T, Zimprich F, Auff E, Zimprich A (2009) Role of LINGO1 polymorphisms in Parkinson’s disease. Mov Disord 24:2404–2407PubMedCentral PubMed
  11.Homma S, Shimada T, Hikake T, Yaginuma H (2009) Expression pattern of LRR and Ig domain-containing protein (LRRIG protein) in the early mouse embryo. Gene Expr Patterns 9:1–26CrossRef PubMed
  12.Hughes AJ, Daniel SE, Kilford L, Lees AJ (1992) Accuracy of clinical diagnosis of idiopathic Parkinson’s disease: a clinico-pathological study of 100 cases. J Neurol Neurosurg Psychiatry 55:181–184PubMedCentral CrossRef PubMed
  13.Inoue H, Lin L, Lee X, Shao Z, Mendes S, Snodgrass-Belt P, Sweigard H, Engber T, Pepinsky B, Yang L, Beal MF, Mi S, Isacson O (2007) Inhibition of the leucine-rich repeat protein LINGO-1 enhances survival, structure, and function of dopaminergic neurons in Parkinson’s disease models. Proc Natl Acad Sci USA 104:14430–14435PubMedCentral CrossRef PubMed
  14.Klebe S, Thier S, Lorenz D, Nothnagel M, Schreiber S, Klein C, Hagenah J, Kasten M, Berg D, Srulijes K, Gasser T, Deuschl G, Kuhlenbaumer G (2010) LINGO1 is not associated with Parkinson’s disease in German patients. Am J Med Genet Part B Neuropsychiatr Genet 153b:1173–1178
  15.Lang AE, Lozano AM (1998) Parkinson’s disease. First of two parts. N Eng J Med 339:1044–1053CrossRef
  16.Lettre G, Lange C, Hirschhorn JN (2007) Genetic model testing and statistical power in population-based association studies of quantitative traits. Genet Epidemiol 31:358–362CrossRef PubMed
  17.Litvan I, Bhatia KP, Burn DJ, Goetz CG, Lang AE, McKeith I, Quinn N, Sethi KD, Shults C, Wenning GK (2003) Movement Disorders Society Scientific Issues Committee report: SIC Task Force appraisal of clinical diagnostic criteria for Parkinsonian disorders. Mov Disord 18:467–486CrossRef PubMed
  18.Llorens F, Gil V, Iraola S, Carim-Todd L, Marti E, Estivill X, Soriano E, del Rio JA, Sumoy L (2008) Developmental analysis of Lingo-1/Lern1 protein expression in the mouse brain: interaction of its intracellular domain with Myt1l. Dev Neurobiol 68:521–541CrossRef PubMed
  19.Lorenzo-Betancor O, Samaranch L, Garcia-Martin E, Cervantes S, Agundez JA, Jimenez-Jimenez FJ, Alonso-Navarro H, Luengo A, Coria F, Lorenzo E, Irigoyen J, Pastor P (2011) LINGO1 gene analysis in Parkinson’s disease phenotypes. Mov Disord 26:722–727CrossRef PubMed
  20.Mi S, Lee X, Shao Z, Thill G, Ji B, Relton J, Levesque M, Allaire N, Perrin S, Sands B, Crowell T, Cate RL, McCoy JM, Pepinsky RB (2004) LINGO-1 is a component of the Nogo-66 receptor/p75 signaling complex. Nat Neurosci 7:221–228CrossRef PubMed
  21.Mi S, Sandrock A, Miller RH (2008) LINGO-1 and its role in CNS repair. Int J Biochem Cell Biol 40:1971–1978CrossRef PubMed
  22.Stefanova N, Bucke P, Duerr S, Wenning GK (2009) Multiple system atrophy: an update. Lancet Neurol 8:1172–1178CrossRef PubMed
  23.Su FC, Chen CM, Chen YC, Wu YR (2012) LINGO-2 polymorphism and the risk of Parkinson’s disease in Taiwan. Parkinsonism Relat Disord 18:609–611CrossRef PubMed
  24.Vilarino-Guell C, Ross OA, Wider C, Jasinska-Myga B, Cobb SA, Soto-Ortolaza AI, Kachergus JM, Keeling BH, Dachsel JC, Melrose HL, Behrouz B, Wszolek ZK, Uitti RJ, Aasly JO, Rajput A, Farrer MJ (2010) LINGO1 rs9652490 is associated with essential tremor and Parkinson disease. Parkinsonism Relat Disord 16:109–111PubMedCentral CrossRef PubMed
  25.Vilarino-Guell C, Wider C, Ross OA, Jasinska-Myga B, Kachergus J, Cobb SA, Soto-Ortolaza AI, Behrouz B, Heckman MG, Diehl NN, Testa CM, Wszolek ZK, Uitti RJ, Jankovic J, Louis ED, Clark LN, Rajput A, Farrer MJ (2010) Analysis of LINGO1 (rs9652490) polymorphism in sporadic Parkinson’s disease in a Polish population, and a meta-analysis. Neurogenetics 11:401–408PubMedCentral CrossRef PubMed
  26.Vilarino-Guell C, Wider C, Ross OA, Jasinska-Myga B, Kachergus J, Cobb SA, Soto-Ortolaza AI, Behrouz B, Heckman MG, Diehl NN, Testa CM, Wszolek ZK, Uitti RJ, Jankovic J, Louis ED, Clark LN, Rajput A, Farrer MJ (2010) LINGO1 and LINGO2 variants are associated with essential tremor and Parkinson disease. Neurogenetics 11:401–408PubMedCentral CrossRef PubMed
  27.Wenning GK, Colosimo C, Geser F, Poewe W (2004) Multiple system atrophy. Lancet Neurol 3:93–103CrossRef PubMed
  28.Wu Y, Wang X, Xu W, Liu W, Fang F, Ding J, Song Y, Chen S (2012) Genetic variation in LINGO-1 (rs9652490) and risk of Parkinson’s disease: twelve studies and a meta-analysis. Neurosci Lett 522:67–72CrossRef PubMed
  29.Wu YR, Tan EK, Chen CM, Kumar PM, Lee-Chen GJ, Chen ST (2011) Genetic analysis of “leucine-rich repeat (LRR) and immunoglobulin (Ig) domain-containing, Nogo receptor-interacting protein-1 (LINGO1)” in two independent Chinese parkinson’s disease populations. Am J Med Genet Part B Neuropsychiatr Genet 156b:99–103CrossRef
  30.Wu YW, Prakash KM, Rong TY, Li HH, Xiao Q, Tan LC, Au WL, Ding JQ, Chen SD, Tan EK (2011) Lingo2 variants associated with essential tremor and Parkinson’s disease. Hum Genet 129:611–615CrossRef PubMed
  31.Zuo X, Jiang H, Guo JF, Yu RH, Sun QY, Hu L, Wang L, Yao LY, Shen L, Pan Q, Yan XX, Xia K, Tang BS (2010) Screening for two SNPs of LINGO1 gene in patients with essential tremor or sporadic Parkinson’s disease in Chinese population. Neurosci Lett 481:69–72CrossRef PubMed
  
• 作者单位：YongPing Chen (1)
  Bei Cao (1)
  Jing Yang (1)
  QianQian Wei (1)
  Ru Wei Ou (1)
  Bi Zhao (1)
  Wei Song (1)
  XiaoYan Guo (1)
  HuiFang Shang (1)
  
  1. Department of Neurology, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, People’s Republic of China
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Neurology
  Neurosciences
  Neuroradiology
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-1459

文摘

Whether polymorphisms rs11856808 and rs9652490 of the Leucine-rich repeat and Ig domain containing, Nogo receptor-interacting protein-1 (LINGO1) gene, as well as rs10968280, rs13362909 and rs7033345 of the LINGO2 gene, increase the risk for Parkinson’s disease (PD) is controversial. Considering the overlap of the clinical and pathological characteristics among PD and multiple system atrophy (MSA), we explored the associations between these five polymorphisms and PD and MSA in a Chinese population. A total of 1055 PD patients, 320 MSA patients, and 810 healthy controls (HCs) were genotyped for these five polymorphisms in LINGO1 and LINGO 2 using Sequenom iPLEX Assay technology. Moreover, after combining our results with available published data, a meta-analysis was conducted to investigate the associations between LINGO 1 rs11856808 and rs9652490 and the risk of PD. The frequency of the minor alleles “T” of LINGO1 rs11856808 was significantly lower in PD than that in HCs (p = 0.011, OR 0.89, 95 % CI 0.81–0.97), but not in MSA. Moreover, there were no significant differences in the minor allele frequency distributions of the other four polymorphisms between PD and HCs, and between MSA and HCs. The meta-analysis showed a lack of association of rs9652490 and PD, regardless of the genetic model or ethnic origin. However, the rs11856808 allele decreased the risk of PD in patients of Asian origin in a dominant genetic model. Our findings suggest that rs11856808 plays a protective role by decreasing the risk for PD, but not for MSA, in Asian population, the other four polymorphisms do not contribute to the risk for PD and MSA.