Synthesis and biological evaluation of fatty acids containing 99mTc-oxo and 99mTc-nitrido for myocardial metabolism imaging

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• 作者：Xiang Li ; Aiqin Wu ; Qianqian Xue ; Yu Fang…
• 关键词：Fatty acid ; 99mTc ; labeled ; Myocardial metabolism imaging ; 99mTc ; oxo core ; 99mTc ; nitrido core
• 刊名：Journal of Radioanalytical and Nuclear Chemistry
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：307
• 期：2
• 页码：1429-1438
• 全文大小：621 KB
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• 作者单位：Xiang Li (1)
  Aiqin Wu (1)
  Qianqian Xue (1)
  Yu Fang (1)
  Jianping Liu (1)
  Huabei Zhang (1)
  Huaying Bao (1)
  
  1. Key Laboratory of Radiopharmaceuticals, Ministry of Education, College of Chemistry, Beijing Normal University, No. 19, XinJieKouWai St., HaiDian District, Beijing, 100875, People’s Republic of China
  
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Nuclear Chemistry
  Physical Chemistry
  Nuclear Physics, Heavy Ions and Hadrons
  Diagnostic Radiology
  Inorganic Chemistry
  
• 出版者：Akad茅miai Kiad贸, co-published with Springer Science+Business Media B.V., Formerly Kluwer Academic
• ISSN：1588-2780

文摘

In this study, four 99mTc-labeled fatty acid analogues including [99mTcO]3+ and [99mTc≡N]2+ cores were successfully synthesized and fully characterized. The radiochemical purity of those compounds was over 90 % and they were stable when incubated in a rat serum for 3 h at 37 °C. The biodistribution studies in mice demonstrated that compounds labeled with [99mTcO]3+ exhibited good uptakes (6.11 %ID/g of [99mTcO]-MAMA-DTA and 3.89 %ID/g of [99mTcO]-MAMA-UTA at 1 min postinjection) and the maximum heart to blood ratio was 5.91 at 30 min postinjection of [99mTcO]-MAMA-DTA. While the others labeled with [99mTc≡N]2+ showed lower uptakes and faster washout from the myocardium. Keywords Fatty acid 99mTc-labeled Myocardial metabolism imaging 99mTc-oxo core 99mTc-nitrido core