Allelic loss of chromosome 3p24 correlates with tumor progression rather than with retinoic acid receptor β2 expression in breast carcinoma

详细信息    查看全文

• 作者：Yang ; Qifeng ; Yoshimura ; Goro ; Sakurai ; Takeo ; Nakamura ; Misa ; Nakamura ; Yasushi ; Shan ; Liang ; Suzuma ; Takaomi ; Tamaki ; Takeshi ; Umemura ; Teiji ; Mori ; Ichiro ; Kakudo ; Kennichi
• 关键词：breast cancer ; chromosome 3p24 ; loss of heterozygosity ; retinoic acid receptor 2
• 刊名：Breast Cancer Research and Treatment
• 出版年：2001
• 出版时间：2001
• 年：2001
• 卷：70
• 期：1
• 页码：39-45
• 全文大小：102 KB

文摘

A tumor suppressor gene, retinoic acid receptor (RAR) β2, has been mapped to chromosome 3p24, a region where loss of heterozygosity (LOH) has been observed commonly in carcinomas of various tumor tissues. RAR β2 expression is reduced or lost in many malignant tumors including breast cancer, however, whether LOH accounts for the loss of expression of RAR β2 in breast cancer is unknown. We, therefore, assessed LOH on chromosome band 3p24 to correlate it with RAR β2 expression and other established prognostic parameters in 52 breast carcinomas. Based on three microsatellites, D3S 1283, D3S 1293 and D3S 1286, all of the tumors were informative, of these, 12 (23%) exhibited LOH. RAR β2 expression was lost in 42% (19/45) of these samples. We found that LOH on chromosome band 3p24 was not correlated with loss of RAR β2, but correlated with higher histological grade, p53-positivity, and loss of estrogen and progesterone receptors. Our findings suggest that LOH of the RAR β2 gene does not account for the frequent loss of RAR β2 expression in breast cancer but the genomic structural alteration at or close to the RAR β2 gene locus are likely to be associated with tumor progression and/or loss of hormonal dependency.