Biodegradable Polymersomes as Nanocarriers for Doxorubicin Hydrochloride: Enhanced Cytotoxicity in MCF-7/ADR Cells and Prolonged Blood Circulation

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• 作者：Yanhui Chao ; Yuheng Liang ; Guihua Fang ; Haibing He ; Qing Yao…
• 关键词：KEY WORDScontrolled ; release ; doxorubicin ; multidrug resistance ; pharmacokinetic ; polymersomes
• 刊名：Pharmaceutical Research
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：34
• 期：3
• 页码：610-618
• 全文大小：
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Pharmacology/Toxicology; Pharmacy; Biochemistry, general; Medical Law; Biomedical Engineering;
• 出版者：Springer US
• ISSN：1573-904X
• 卷排序：34

文摘

PurposeDOX is one of the most potent anticancer drugs. But its short half-life and the occurrence of multi-drug resistance (MDR) markedly limit its clinical application. To solve these problems, we develop DOX loaded polymersomes (DOX polymersomes).