Grouping miRNAs of similar functions via weighted information content of gene ontology

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• 作者：Chaowang Lan ; Qingfeng Chen ; Jinyan Li
• 关键词：Gene ontology ; Functions of miRNAs ; Information content ; GO graphs ; Spectral clustering
• 刊名：BMC Bioinformatics
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：17
• 期：19-supp
• 全文大小：767KB
• 刊物主题：Bioinformatics; Microarrays; Computational Biology/Bioinformatics; Computer Appl. in Life Sciences; Algorithms;
• 出版者：BioMed Central
• ISSN：1471-2105
• 卷排序：17

文摘

BackgroundRegulation mechanisms between miRNAs and genes are complicated. To accomplish a biological function, a miRNA may regulate multiple target genes, and similarly a target gene may be regulated by multiple miRNAs. Wet-lab knowledge of co-regulating miRNAs is limited. This work introduces a computational method to group miRNAs of similar functions to identify co-regulating miRNAsfrom a similarity matrix of miRNAs.