Duck tembusu virus and its envelope protein induce programmed cell death

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• 作者：Wulin Shaozhou ; Chenxi Li ; Qingshan Zhang ; Runzhe Meng ; Youlan Gao…
• 关键词：Flaviviruses ; Duck tembusu virus ; Envelope glycoprotein E ; Apoptosis ; DEVDase activity
• 刊名：Virus Genes
• 出版年：2015
• 出版时间：August 2015
• 年：2015
• 卷：51
• 期：1
• 页码：39-44
• 全文大小：1,139 KB
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• 作者单位：Wulin Shaozhou (1)
  Chenxi Li (1)
  Qingshan Zhang (1)
  Runzhe Meng (1)
  Youlan Gao (1)
  Hongyu Liu (1)
  Xiaofei Bai (1)
  Yuhuan Chen (1)
  Ming Liu (1)
  Siguo Liu (1)
  Yun Zhang (1)
  
  1. State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute of Chinese Academy of Agricultural Sciences, Harbin, 150001, China
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Medical Microbiology
  Virology
  Plant Sciences
  
• 出版者：Springer Netherlands
• ISSN：1572-994X

文摘

The cytopathic effect produced in cells infected with duck tembusu virus (DTMUV) suggests that this emerging virus may induce apoptosis in primary cultures of duck embryo fibroblasts (DEF). Here, we present evidence that DTMUV infection of cultured cells activates apoptosis and that the ability of DTMUV to induce apoptosis is not restricted to cell type because DTMUV-induced apoptosis in duck and mammalian host cells. We further investigated which viral components induce apoptosis in DTMUV-infected host cells. The major envelope glycoprotein (E) was investigated for its apoptotic activities in expressed cells. Transient expression of the E protein alone triggered apoptosis in DEF, Vero, and BHK cells. Expression of the E protein resulted in activation of caspase-3-like proteases in cultured cells. These results indicate that infection of cells with DTMUV or expression of DTMUV E protein alone induces apoptosis, providing the basis for future to define the molecules that play key roles in the fate of DTMUV-infected cells.